Phospho-KIRREL Antibody

Product no.: PNEPH-140AP

$375.00

Description

General Information
Product	Phospho KIRREL Antibody
Description	Affinity Purified kin of IRRE-like protein 1 Antibody C-epitope
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Chicken, Human, Mouse, Rat, Zebra Fish
Immunogen	Phosphorylated synthetic peptide with phospo tyrosine 737 and 738 on mouse Kin of IRRE-like protein 1.
Specificity	Intracelular domain.
Accession #	NCBI: NP_060710.3
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.45-0.65 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Determinant	C-epitope
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:250
Dot Blot	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:250
Immunofluorescence	1:250
Immunohistochemistry	1:250
Immunoprecipitation	1:250
Western Blot	1:250
Protein
Uniprot #	Q80W68
Overview	Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
Molecular Function	Myosin Binding
Subcellular Location	Cell membrane; Single-pass type I membrane protein
Expression	Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
Structure	Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL glycosylation. Homodimer (via the Ig-like domains). Interacts when tyrosine-phosphorylated with GRB2.
Alternative Nomenclature	FLJ10845 antibody Kin of IRRE like protein 1 antibody Kirrel antibody NEPH1 antibody Nephrin like protein 1 antibody

Protein information supplied by UniProt