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General Information
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Product
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Phospho PRP19 Antibody
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Description
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Affinity Purified Phosphorylated pre-mRNA-processing factor 19 Antibody
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Verified Applications
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ELISA, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse
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Immunogen
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Phosphorylated synthetic peptide taken within amino acid region 200-300 on rat PRP19F protein.
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Accession #
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NCBI: NP_647549
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.50-0.75 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:2,000
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ELISA
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1:2,000
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Western Blot
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1:500-1:1,000
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Protein
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Uniprot #
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Q9JMJ4
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Overview
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Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3.
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Molecular Function
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Ligase, DNA binding, ubiquitin-ubiquitin ligase activity
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Structure
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Homotetramer. Component of the Prp19 complex/PRP19C/Nineteen complex/NTC and related complexes described as PRP19-CDC5L splicing complex and PSO4 complex. A homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2 constitute the core of those complexes. The interaction with CDC5L, PLRG1 and BCAS2 is direct within this core complex.
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Alternative Nomenclature
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hPso4 antibody
NMP200 antibody
Nuclear matrix protein 200 antibody
pre mRNA processing factor 19 antibody
PRP19 antibody
PRP19/PSO4 homolog antibody
PRPF19 antibody
PSO4 antibody
psoralen 4 antibody
Senescence evasion factor antibody
SNEV antibody
UBOX4 antibody
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Phospho-PRP19 Antibody FITC
Phospho-PRP19 Antibody BIOTIN
Phospho-PRP19 Blocking Peptide
Phospho-PRP19 Positive Control
