|
General Information
|
|
|
Product
|
Presenilin 1 Antibody
|
|
Description
|
Affinity Purified Presenilin 1 (Alzheimer disease 3) Antibody C-epitope
|
|
Verified Applications
|
ELISA, IHC, IP, WB
|
|
Host
|
Rabbit
|
|
Species Cross Reactivity
|
Bovine, Cat, Human, Monkey, Pig, Rat
|
|
Immunogen
|
Synthetic peptide taken within amino acid region 417-467 on human Presnelin-1 protein.
|
|
Accession #
|
GenBank: EAW81096.1
|
|
Physical Properties
|
|
|
Quantity
|
100 µg
|
|
Volume
|
200 µl
|
|
Concentration
|
1.00-1.25 µg/µl in antibody stabilization buffer
|
|
Form
|
Affinity Purified
|
|
Clonality
|
Polyclonal
|
|
Determinant
|
C-epitope
|
|
Storage
|
-20⁰C for long term storage
|
|
Application Protocol
|
|
DB
|
1:10,000
|
|
ELISA
|
1:10,000
|
| Immunohistochemistry |
1:50-1:150 |
|
Immunoprecipitation
|
1:150
|
|
Western Blot
|
1:500
|
|
Protein
|
|
Uniprot #
|
P49768
|
|
Overview
|
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
|
|
Molecular Function
|
Hydrolase, Protease
|
|
Subcellular Location
|
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface
|
|
Expression
|
Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes.
|
|
Structure
|
Homodimer
|
|
Alternative Nomenclature
|
AD3 antibody
FAD antibody
Homo Sapiens Clone CC44 Senilin 1 antibody
Presenilin-1 CTF12 antibody
Protein S182 antibody
PS 1 antibody
PSEN1 antibody
S182 antibody
|
| |
|
Presenilin 1 Antibody FITC
Presenilin 1 Antibody BIOTIN
Presenilin 1 Blocking Peptide
Presenilin 1 Positive Control
