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General Information
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Product
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Phospho-STAT3 Antibody
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Description
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Affinity Purified Phosphorylated Signal transducer and activator of transcription Antibody
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Verified Applications
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ELISA, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Phosphorylated synthetic peptide taken within amino acid region 700-750 on human STAT3 protein.
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Accession #
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NCBI: NP_644805
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.55-0.75 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Western Blot
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1:500
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Protein
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Uniprot #
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P40763
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Overview
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Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes.
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Molecular Function
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Activator, calcium ion binding, DNA binding
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Subcellular Location
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Cytoplasm. Nucleus
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Expression
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Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
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Structure
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Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1. Interacts with HCV core protein. Interacts with IL23R in presence of IL23. Interacts (via SH2 domain) with NLK. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity).
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Alternative Nomenclature
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Acute Phase Response Factor antibody
APRF antibody
DNA binding protein APRF antibody
HIES antibody
Signal Transductor and Activator of Transcription 3 antibody
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Phospho-STAT3 Antibody FITC
Phospho-STAT3 Antibody BIOTIN
Phospho-STAT3 Blocking Peptide
Phospho-STAT3 Positive Control
