Phospho-STAT3 Antibody

General Information

Product

Phospho-STAT3 Antibody

Description

Affinity Purified Phosphorylated Signal transducer and activator of transcription Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Phosphorylated synthetic peptide taken within amino acid region 700-750 on human STAT3 protein.

Accession #

NCBI:  NP_644805

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P40763

Overview

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes.

Molecular Function

Activator, calcium ion binding, DNA binding

Subcellular Location

Cytoplasm. Nucleus

Expression

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Structure

Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1. Interacts with HCV core protein. Interacts with IL23R in presence of IL23. Interacts (via SH2 domain) with NLK. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity).

Alternative Nomenclature

Acute Phase Response Factor antibody

APRF antibody

DNA binding protein APRF antibody

HIES antibody

Signal Transductor and Activator of Transcription 3 antibody