RIPK3 Antibody

Product no.: RIPK3-301AP
$295.00
$265.00


2_30

General Information

 

 

Product

 

RIPK3 Antibody Affinity Purified

Description

Affinity Purified Receptor-interacting Serine/Threonine-protein kinase 3 Antibody C-epitope

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Pig, Monkey

Immunogen

Synthetic peptide taken within amino acid region 461-511 on human Receptor-interacting Serine/Threonine-protein kinase 3 protein.

Accession #

NCBINP_006862.2


Physical Properties

 

Quantity

 

100 µg

Volume

200 µl

Concentration

0.66-0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20C for long term storage


Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500


Protein

 

Uniprot #

 

Q9Y572

Overview

Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL.

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Cytoplasm, Cell membrane, Mitochondrion

Expression

Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.

Structure

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Alternative Nomenclature

Receptor interacting protein 3 antibody

Receptor interacting serine threonine kinase 3 antibody

Receptor-interacting protein 3 antibody

RIP 3 antibody

RIP like protein kinase 3 antibody

RIPK 3 antibody

Protein information supplied by UniProt
 


Accessories

Product Note Status Price
RIPK3 Antibody FITC RIPK3 Antibody FITC
RIPK3.301-FITC $350.00 *
RIPK3 Antibody BIOTIN RIPK3 Antibody BIOTIN
RIPK3.301-BIOTIN $350.00 *
RIPK3 Blocking Peptide RIPK3 Blocking Peptide
P-RIPK3.301 $145.00 *
RIPK3 Positive Control RIPK3 Positive Control
PC-RIPK3 $185.00 *
Display accessory details

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