|
General Information
|
|
|
Product
|
RIPK3 Antibody Affinity Purified
|
|
Description
|
Affinity Purified Receptor-interacting Serine/Threonine-protein kinase 3 Antibody C-epitope
|
|
Verified Applications
|
ELISA, IMM, WB
|
|
Host
|
Rabbit
|
|
Species Cross Reactivity
|
Bovine, Human, Pig, Monkey
|
|
Immunogen
|
Synthetic peptide taken within amino acid region 461-511 on human Receptor-interacting Serine/Threonine-protein kinase 3 protein.
|
|
Accession #
|
NCBI: NP_006862.2
|
|
Physical Properties
|
|
|
Quantity
|
100 µg
|
|
Volume
|
200 µl
|
|
Concentration
|
0.66-0.68 µg/µl in antibody stabilization buffer
|
|
Form
|
Affinity Purified
|
|
Clonality
|
Polyclonal
|
|
Determinant
|
C-epitope
|
|
Storage
|
-20⁰C for long term storage
|
|
Application Protocol
|
|
DB
|
1:10,000
|
|
ELISA
|
1:10,000
|
|
Immunoprecipitation
|
1:200
|
|
Western Blot
|
1:500
|
|
Protein
|
|
Uniprot #
|
Q9Y572
|
|
Overview
|
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL.
|
|
Molecular Function
|
Kinase, Serine/threonine-protein kinase, Transferase
|
|
Subcellular Location
|
Cytoplasm, Cell membrane, Mitochondrion
|
|
Expression
|
Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.
|
|
Structure
|
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Contains 1 protein kinase domain.
|
|
Alternative Nomenclature
|
Receptor interacting protein 3 antibody
Receptor interacting serine threonine kinase 3 antibody
Receptor-interacting protein 3 antibody
RIP 3 antibody
RIP like protein kinase 3 antibody
RIPK 3 antibody
|
|
|
|
RIPK3 Antibody FITC
RIPK3 Antibody BIOTIN
RIPK3 Blocking Peptide
RIPK3 Positive Control
