ROCK2 Antibody

Product no.: ROCK2-201AP

$285.00

Description
Publications

General Information
Product	ROCK2 Antibody
Description	Affinity Purified Rho-associated protein kinase 2 Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 1300-1388 on human ROCK2 protein.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.57 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DOT Blot	1:10,000
ELISA	1:10,000
Immunohistochemistry	1:50-1:100
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	O75116
Overview	Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4.
Molecular Function	Kinase, Serine/threonine-protein kinase, Transferase
Subcellular Location	Cytoplasm, Cell membrane; Peripheral membrane protein, Nucleus
Structure	Homodimer. Interacts with IRS1, RHOB and RHOC. Interacts with RHOA (activated by GTP), PPP1R12A, CHORDC1, SORL1, EP300 and BRCA2. Interacts with NPM1 and this interaction enhances its activity. Interacts with RAF1.
Alternative Nomenclature	coiled-coil-containing protein kinase 2 antibody KIAA0619 antibody p164 ROCK 2 antibody Rho associated, coiled coil containing protein kinase II antibody ROK alpha antibody

Protein information supplied by UniProt