General Information
|
|
Product
|
SREBP2 Antibody
|
Description
|
Affinity Purified Sterol regulatory element binding protein-2 Antibody
|
Verified Applications
|
ELISA, IP, WB
|
Host
|
Rabbit
|
Species Cross Reactivity
|
Human, Mouse, Rat
|
Immunogen
|
Synthetic peptide taken within amino acid region 640-690 on human Sterol regulatory element binding protein-2.
|
Accession #
|
GenBank: AAA50746.1
|
Physical Properties
|
|
Quantity
|
100 µg
|
Volume
|
200 µl
|
Concentration
|
0.64-0.72 µg/µl in antibody stabilization buffer
|
Form
|
Affinity Purified
|
Clonality
|
Polyclonal
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
DB
|
1:10,000
|
ELISA
|
1:10,000
|
Immunoprecipitation
|
1:150
|
Western Blot
|
1:500
|
Protein
|
Uniprot #
|
Q12772
|
Overview
|
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.
|
Molecular Function
|
Activator, E-box binding, protein C-terminus binding
|
Subcellular Location
|
Endoplasmic reticulum membrane; Multi-pass membrane protein, Golgi apparatus membrane; Multi-pass membrane protein, Cytoplasmic vesicle > COPII-coated vesicle membrane; Multi-pass membrane protein
|
Expression
|
Ubiquitously expressed in adult and fetal tissues.
|
Structure
|
Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. Component of SCAP/SREBP complex composed of SREBF2, SCAP and RNF13.
|
Alternative Nomenclature
|
AI608257 antibody
bHLHd2 antibody
Class D basic helix-loop-helix protein 2 antibody
Processed sterol regulatory element-binding protein 2 antibody
SREBF 2 antibody
SREBP2 antibody
Sterol regulatory element-binding transcription factor 2 antibody
|
|
|