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General Information
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Product
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Somatostatin Receptor 2 Antibody
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Description
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Affinity Purified Somatostatin receptor type 2 / SSTR2 Antibody
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 300-350 on human Somatostatin receptor type 2 / SSTR2.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5-1.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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Affinity Purified
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:50,000
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Immunoprecipitation
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1:200
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Western Blot
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1:500
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Protein
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Uniprot #
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P30874
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Overview
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Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B.
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Molecular Function
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G protein-coupled receptor activity Source: GO_Central
neuropeptide binding Source: GO_Central
PDZ domain binding Source: UniProtKB
peptide binding Source: GO_Central
somatostatin receptor activity
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Subcellular Location
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Cell membrane, Cytoplasm, Membrane
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Expression
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Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the
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Structure
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Transmembrane, Transmembrane helix
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Alternative Nomenclature
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Somatostatin receptor type 2 antibody
SRIF-1 antibody
SS-2-R antibody
SS2R antibody
SST2 antibody
SSTR2 antibody
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Somatostatin Receptor 2 Antibody BIOTIN
Somatostatin Receptor 2 Antibody FITC
Somatostatin Receptor 2 Blocking Peptide
Somatostatin Receptor 2 Positive Control
