Syncytin A Antibody

Product no.: SYCY1-101AP
$285.00


General Information

 

 

Product

 

Syncytin A Antibody

Description

Affinity Purified Envelope glycoprotein syncytin-A Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 180-230 on rat Envelope glycoprotein syncytin-A protein.


Physical Properties

 

 

Quantity

 

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20C for long term storage


Application Protocol

 

ELISA

 

1:50,000

Immunohistochemistry 1:50-1:100

Immunoprecipitation

1:200

Western Blot

1:500


Protein

 

Uniprot #

 

Q5G5D4

Overview

This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904).3 Publications

Endogenous envelope proteins may have kept, lost or modified their original function during evolution.

Molecular Function

Anatomical structure morphogenesis, syncytium formation

Subcellular Location

Cell membrane

Expression

Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia.

Structure

The cytoplasmic region is essential for the fusiogenic function.

The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.

Alternative Nomenclature

Endogenous retrovirus group W member 1 antibody
env antibody
Env-W antibody
Envelope polyprotein gPr73 antibody
Enverin antibody
ERVW antibody
ERVW-1 antibody
Gp24 antibody
Gp50 antibody
HERV-7q Envelope protein antibody
HERV-W envelope protein antibody
HERVW antibody
SU antibody
Syncytin A antibody
TM antibody
Transmembrane protein antibody

   

Protein information supplied by UniProt

Accessories

Product Note Status Price
Syncytin A Antibody BIOTIN Syncytin A Antibody BIOTIN
SYCY1-BIOTIN $375.00 *
Syncytin A Antibody FITC Syncytin A Antibody FITC
SYCY1-FITC $375.00 *
Syncytin A Blocking Peptide Syncytin A Blocking Peptide
P-SYCY1 $155.00 *
Syncytin A Positive Control Syncytin A Positive Control
PC-SYCY1 $200.00 *
Display accessory details

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