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General Information
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Product
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TLR4 Antibody Affinity Purified
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Description
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Affinity Purified Toll-like receptor 4 Antibody
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Verified Applications
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ELISA, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human
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Immunogen
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Synthetic peptide taken within amino acid region 970-1000 on human TLR4 protein.
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Accession #
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GenBank: AAF05316.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.66-0.8 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:20,000
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ELISA
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1:20,000
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Western Blot
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1:500
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Protein
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Uniprot #
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O00206
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Overview
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Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+.
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Molecular Function
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Receptor, lipopolysaccharide binding, transmembrane signaling receptor activity
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Subcellular Location
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Cell membrane; Single-pass type I membrane protein
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Expression
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Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells.
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Structure
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Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via the
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Alternative Nomenclature
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ARMD10 antibody
CD284 antibody
Homolog of Drosophila toll antibody
hToll antibody
TLR 4 antibody
Toll (Drosophila) homolog antibody
TOLL antibody
Toll Endotoxin Hyporesponsiveness antibody
Toll like receptor 4 antibody
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TLR4 Antibody FITC
TLR4 Antibody BIOTIN
TLR4 Blocking Peptide
TLR4 Positive Control
