TLR4 Antibody

General Information

Product

TLR4 Antibody Affinity Purified

Description

Affinity Purified Toll-like receptor 4 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 970-1000 on human TLR4 protein.

Accession #

GenBank: AAF05316.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.66-0.8 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000

ELISA

1:20,000

Western Blot

1:500

Protein

Uniprot #

O00206

Overview

Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+.

Molecular Function

Receptor, lipopolysaccharide binding, transmembrane signaling receptor activity

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Expression

Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells.

Structure

Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via the

Alternative Nomenclature

ARMD10 antibody

CD284 antibody

Homolog of Drosophila toll antibody

hToll antibody

TLR 4 antibody

Toll (Drosophila) homolog antibody

TOLL antibody

Toll Endotoxin Hyporesponsiveness antibody

Toll like receptor 4 antibody