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General Information
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Product
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TLR6 Antibody
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Description
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Affinity Purified Toll-like receptor 6 Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Cat, Human, Mouse, Rat, Pig
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Immunogen
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Synthetic peptide taken within amino acid region 195-225 on human TLR6 protein.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.78-0.80 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:20,000
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ELISA
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1:20,000
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| Immunohistochemistry |
1:100 |
| Immunoprecipitation |
1:200 |
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Western Blot
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1:500
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Protein
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Uniprot #
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Q9Y2C9
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Overview
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Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2.
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Molecular Function
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Receptor, diacyl lipopeptide binding, transmembrane signaling receptor activity
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Subcellular Location
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Cell membrane; Single-pass type I membrane protein, Cytoplasmic vesicle > phagosome membrane; Single-pass type I membrane protein
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Expression
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Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.
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Structure
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Binds MYD88 via their respective TIR domains. Heterodimer with TLR2 via their respective extracellular domains (By similarity). Interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR4. The trimeric complex is internalized and triggers inflammatory response. LYN kinase activity facilitates TLR4-TLR6 heterodimerization and signal initation.
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Alternative Nomenclature
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CD286 antibody
TLR 6 antibody
Toll like receptor 6 precursor antibody
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TLR6 Antibody FITC
TLR6 Antibody BIOTIN
TLR6 Blocking Peptide
TLR6 Positive Control
