TLR9 Antibody

General Information

Product

TLR9 Antibody

Description

Affinity Purified Toll-like receptor 9 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Chimpanzee, Human, Monkey, Rat

Immunogen

Synthetic peptide taken within amino acid region 430-460 on human TLR9 protein.

Accession #

GenBank: AAQ89443.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.57-0.76 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000

ELISA

1:20,000

Western Blot

1:500

Protein

Uniprot #

Q9NR96

Overview

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides.

Molecular Function

Receptor, Interleukin-1 receptor binding, siRNA binding

Subcellular Location

Endoplasmic reticulum membrane; Single-pass type 1 membrane protein, Endosome, Lysosome, Cytoplasmic vesicle

Expression

Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.

Structure

Interacts with MYD88 via their respective TIR domains (By similarity). Interacts (via transmembrane domain) with UNC93B1 (By similarity). Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses.

Alternative Nomenclature

CD 289 antibody

TLR 9 antibody

Toll like receptor 9 isoform A precursor antibody

Toll like receptor 9 isoform B antibody