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General Information
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Product
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TICAM2 Antibody
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Description
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Affinity Purified TRIF-related adapter molecule Antibody
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Verified Applications
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DB, ELISA, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide corresponding to unique amino acid sequences on TRIF-related adapter molecule.
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Accession #
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GenBank: AAO74498.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.50-0.75 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:20,000
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ELISA
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1:20,000
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Western Blot
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1:500-1:750
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Protein
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Uniprot #
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Q86XR7
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Overview
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Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.
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Molecular Function
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phospholipid binding, signal transducer activity
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Subcellular Location
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Isoform 1 : Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome membrane. Late endosome membrane, Isoform 2 : Endoplasmic reticulum. Early endosome membrane. Late endosome membrane, Isoform 2 : Endoplasmic reticulum.
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Expression
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Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1).
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Structure
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Homodimer. Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS. Interacts with IL1R1, IL1RAP, IRAK2, IRAK3 and TRAF6. Interacts with protein kinase-inactive mutants of IRAK1 and IRAK4. Isoform 1 interacts with isoform 2; the interaction occurs i
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Alternative Nomenclature
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Putative NF-kappa-B-activating protein 502 antibody
TICAM2 antibody
TIR containing adapter molecule 2 antibody
TIR domain-containing adapter molecule 2 antibody
TIRAP3 antibody
TIRP antibody
Toll-like receptor adaptor protein 3 antibody
Toll/interleukin-1 receptor domain-containing protein antibody
TRAM antibody
TRIF-related adapter molecule antibody
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TICAM2 Antibody FITC
TICAM2 Antibody BIOTIN
TICAM2 Blocking Peptide
TICAM2 Positive Control
