TREX1 Antibody

Product no.: TREX1-101AP
$295.00
$265.00


General Information

 

 

Product

 

TREX1 Antibody

Description

Affinity Purified Three-prime repair exonuclease 1 Antibody

Verified Applications

ELISA, IHC, IF, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 220-245 on human TREX1 protein.

Specificity This antibody is specific for TREX1. This antibody will not detect TREX2.


Physical Properties

 

 

Quantity

 

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20C for long term storage


Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunohistochemistry 1:50-1:100
Immunofluorescence 1:100
Immunoprecipitation 1:200

Western Blot

1:500


Protein

 

Uniprot #

 

Q9NSU2

Overview

Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements.

Molecular Function

Exonucleus, Hydrolase, Nuclease

Subcellular Location

Nucleus, Cytoplasm, Endoplasmic reticulum membrane; Peripheral membrane protein

Expression

Detected in thymus, spleen, liver, brain, heart, small intestine and colon.

Structure

Homodimer. Interacts (via proline-rich region) with TCERG1/CA150 (via the second WW domain). Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Within this complex, directly interacts with SET; this interaction does not result in TREX1 inhibition.

Alternative Nomenclature

3' 5' exonuclease TREX1 antibody

3' repair exonuclease 1 antibody

AGS1 antibody

AGS5 antibody

CRV antibody

Deoxyribonuclease III, dnaQ/mutD (E. coli) like antibody

DKFZp434J0310 antibody

DNase III antibody

DRN3 antibody

HERNS antibody

Three prime repair exonuclease 1 antibody

TREX1 antibody

   

Protein information supplied by UniProt

 

Accessories

Product Note Status Price
TREX1 Antibody FITC TREX1 Antibody FITC
TREX1-FITC $350.00 *
TREX1 Antibody BIOTIN TREX1 Antibody BIOTIN
TREX1-BIOTIN $350.00 *
TREX1 Blocking Peptide TREX1 Blocking Peptide
P-TREX1 $145.00 *
TREX1 Positive Control TREX1 Positive Control
PC-TREX1 $185.00 *
Display accessory details

Browse these categories as well: DNA Damage Response, Autoimmune, Primaries, Metabolism & Homeostasis, Regulation