TREX1 Antibody BIOTIN

Product no.: TREX1-BIOTIN
$375.00


General Information

 

 

Product

 

TREX1 Antibody BIOTIN-Conjugated

Description

BIOTIN-Conjugated Three-prime repair exonuclease 1 Antibody

Verified Applications

ELISA, IHC, IF, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 220-245 on human TREX1 protein.

Specificity This antibody is specific for TREX1. This antibody will not detect TREX2.


Physical Properties

 

 

Quantity

 

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

BIOTIN-Conjugated

Clonality

Polyclonal

Storage

-20C for long term storage


Application Protocol

ELISA

1:10,000

Immunofluorescence 1:100
Immunohistochemistry 1:50-1:100

Immunoprecipitation

1:200

Western Blot

1:500


Protein

 

Uniprot #

 

Q9NSU2

Overview

Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements.

Molecular Function

Exonucleus, Hydrolase, Nuclease

Subcellular Location

Nucleus, Cytoplasm, Endoplasmic reticulum membrane; Peripheral membrane protein

Expression

Detected in thymus, spleen, liver, brain, heart, small intestine and colon.

Structure

Homodimer. Interacts (via proline-rich region) with TCERG1/CA150 (via the second WW domain). Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. 

Alternative Nomenclature

3' 5' exonuclease TREX1 antibody

3' repair exonuclease 1 antibody

AGS1 antibody

AGS5 antibody

CRV antibody

Deoxyribonuclease III, dnaQ/mutD (E. coli) like antibody

DKFZp434J0310 antibody

DNase III antibody

DRN3 antibody

HERNS antibody

Three prime repair exonuclease 1 antibody

TREX1 antibody

   

Protein information supplied by UniProt 

 

Accessories

Product Note Status Price
TREX1 Blocking Peptide TREX1 Blocking Peptide
P-TREX1 $155.00 *
TREX1 Antibody TREX1 Antibody
TREX1-101AP $285.00 *
TREX1 Antibody FITC TREX1 Antibody FITC
TREX1-FITC $375.00 *
TREX1 Positive Control TREX1 Positive Control
PC-TREX1 $200.00 *
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