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General Information
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Product
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TSG101 Antibody FITC
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Description
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FITC-Conjugated Tumor susceptibility gene 101 protein Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 330-390 on Tumor susceptibility gene 101 protein.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5-1.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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FITC-Conjugated
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:10,000
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Immunocytochemistry
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1:50-1:150
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Immunohistochemistry
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1:50-1:150
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Immunoprecipitation
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1:200
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Western Blot
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1:500
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Protein
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Uniprot #
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Q99816
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Overview
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Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
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Molecular Function
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calcium-dependent protein binding
DNA binding
ligand-dependent nuclear receptor transcription coactivator activity
protein homodimerization activity
transcription corepressor activity
ubiquitin binding
ubiquitin protein ligase binding
virion binding
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Subcellular Location
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Cytoplasm
Membrane; Peripheral membrane protein
Nucleus
Late endosome membrane; Peripheral membrane protein
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Expression
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Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.
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Alternative Nomenclature
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ESCRT I complex subunit TSG101 antibody
TS101_HUMAN antibody
TSG 10 antibody
TSG 101 antibody
Tumor susceptibility gene 10 antibody
Tumor susceptibility gene 101 antibody
Tumor susceptibility protein antibody
Tumor susceptibility protein isoform 3 antibody
VPS23 antibody
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TSG101 Antibody
TSG101 Antibody BIOTIN
TSG101 Blocking Peptide
TSG101 Positive Control
