|
General Information
|
|
|
Product
|
WWOX3 Antibody
|
|
Description
|
Affinity Purified Oxidoreductase Antibody
|
|
Verified Applications
|
ELISA, IHC, IP, WB
|
|
Host
|
Rabbit
|
|
Species Cross Reactivity
|
Human, Monkey, Rat
|
|
Immunogen
|
Synthetic peptide taken within amino acid region 250-300 on human WWOXdelta5-8 protein.
|
|
Accession #
|
GenBank: AAA21465.1
|
|
Physical Properties
|
|
|
Quantity
|
100 µg
|
|
Volume
|
200 µl
|
|
Concentration
|
0.5-0.75 µg/µl in antibody stabilization buffer
|
|
Form
|
Affinity Purified
|
|
Clonality
|
Polyclonal
|
|
Storage
|
-20⁰C for long term storage
|
|
Application Protocol
|
|
DB
|
1:10,000-1:100,000
|
|
ELISA
|
1:10,000-1:100,000
|
| Immunohistochemistry |
1:50-1:150 |
|
Immunoprecipitation
|
1:200
|
|
Western Blot
|
1:500
|
|
Protein
|
|
Uniprot #
|
Q9NZC7
|
|
Overview
|
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
|
|
Molecular Function
|
Coenzyme binding; protein dimerization activity; cofactor binding;
|
|
Subcellular Location
|
Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus
|
|
Expression
|
Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.
|
|
Structure
|
Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN. Interacts with TNK2. Interacts with TMEM207.
|
|
Alternative Nomenclature
|
D16S432E antibody
FOR antibody
FRA16D antibody
Fragile site FRA16D oxidoreductase antibody
HHCMA56 antibody
PRO0128 antibody
SCAR12 antibody
SDR41C1 antibody
short chain dehydrogenase/reductase family 41C member 1 antibody
WW domain-containing oxidoreductase antibody
wwox antibody
WWOX_HUMAN antibody
|
| |
|
WWOX3 Antibody FITC
WWOX3 Antibody BIOTIN
WWOX3 Blocking Peptide
WWOX3 Positive Control
