ZFP36L2 Antibody

Product no.: ZFP36L2-201AP

$285.00

Description

General Information
Product	ZFP36L2 Antibody
Description	Affinity Purified Zinc finger protein 36, C3H1 type-like 2 Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid reigon 350-400 on human Zinc finger protein 36, C3H1 type-like 2.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.5 µg/µl in antibody stabilization buffer
Immunoglobulin	IgG
Form	Affinity Purified
Purification Method	Immobilized antigen affinity chromatography
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
ELISA	1:10,000
Immunohistochemistry	1:50-1:100
Immunoprecipitation	1:150
Western Blot	1:150-1:500
Protein
Uniprot #	P47974
Overview	mRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit-erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation.
Molecular Function	AU-rich element binding, DNA binding, metal ion binding, mRNA 3'-UTR AU-rich region binding, poly(A) RNA binding, transcription factor activity, sequence-specific DNA binding
Subcellular Location	Cytoplasm, Nucleus
Structure	Repeat, Zinc-finger
Alternative Nomenclature	BRF2 antibody Butyrate response factor 2 antibody C3H1 type-like 2 antibody EGF response factor 2 antibody ERF 2 antibody Protein TIS11D antibody RNF162C antibody TIS11D antibody ZFP36 like 2 antibody ZFP36 ring finger protein like 2 antibody Zinc finger protein 36 antibody Zinc finger protein 36, C3H type like 1 antibody zinc finger protein 36, C3H type like 2 antibody

Protein information supplied by UniProt