Synthetic peptide corresponding to amino acids within region 1100-1150 on human Tyrosine-protein kinase ABL2 / ARG.
Physical Properties
Quantity
100 µg
Volume
200 µl
Concentration
0.5-1.5 µg/µl in antibody stabilization buffer
Immunoglobulin
IgG
Form
BIOTIN-Conjugated
Purification Method
Immobilized antigen affinity chromatography
Clonality
Polyclonal
Storage
-20?C for long term storage
Application Protocol
ELISA
1:50,000
Immunoprecipitation
1:200
Western Blot
1:500-1:5,000
Protein
Uniprot #
P42684
Overview
Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35.
Molecular Function
actin filament binding
actin monomer binding
ATP binding
magnesium ion binding
manganese ion binding
non-membrane spanning protein tyrosine kinase activity