General Information
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Product
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MAPK13 Antibody
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Description
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Affinity Purified Mitogen-activated protein kinase 13 Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Chicken
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 310-360 on human Mitogen-activated protein kinase 13.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgY
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:10,000
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Immunohistochemistry |
1:50-1:150 |
Immunoprecipitation
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1:150
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Western Blot
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1:500
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Protein
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Uniprot #
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O15264
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Overview
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Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms.
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Molecular Function
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Kinase, Serine/threonine-protein kinase, Transferase
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Subcellular Location
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Cytosol
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Expression
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Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.
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Structure
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The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
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Alternative Nomenclature
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MAP kinase 13 antibody
MAPK 13 antibody
Mitogen activated protein kinase 13 antibody
p38 delta antibody
PRKM13 antibody
SAPK 4 antibody
Stress activated protein kinase 4 antibody
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