General Information |
|
Product |
CX3CL1 Positive Control |
Description |
Western Blot Positive Control Fractalkine |
Verified Applications |
WB |
Immunogen |
Purified protein |
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|
Quantity |
5 Applications |
Volume |
Inquire |
Form |
Western Blot Positive Control |
Purification Method |
Immobilized antigen affinity chromatography |
Storage |
-20⁰C for long term storage |
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|
Western Blot |
1:500 |
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Uniprot # |
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Overview |
Acts as a ligand for both CX3CL1 and integrins. Binds to CX3CR1 and to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1. The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9177350, PubMed:10382755). |
Molecular Function |
CCR chemokine receptor binding, chemokine activity, CX3C chemokine receptor binding, integrin binding |
Subcellular Location |
Cell membrane, Single-pass type I membrane protein, Processed fractalkine : Secreted |
Expression |
Highest levels in brain. Lower levels in kidney, heart and lung. Also found in skeletal muscle and testis. |
Structure |
Signal, Transmembrane, Transmembrane helix |
Alternative Nomenclature |
A 152E5.2 antibody AB030188 antibody ABCD3 antibody AI848747 antibody C-X3-C motif chemokine 1 antibody C3Xkine antibody Chemokine C X3 C motif ligand 1 antibody CX3C membrane anchored chemokine antibody Cx3cl1 antibody CXC3 antibody CXC3C antibody D8Bwg0439e antibody FKN antibody Fractalkine antibody Neurotactin antibody NTN antibody NTT antibody Processed fractalkine antibody SCYD 1 antibody Small inducible cytokine D1 antibody X3CL1_HUMAN antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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CX3CL1-101AP | |||
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CX3CL1-BIOTIN | |||
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CX3CL1-FITC | |||
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P-CX3CL1 | |||
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