General Information |
|
Product |
BACE2 A/C Peptide |
Description |
Antigenic Blocking Peptide Beta Secretase beta-site APP cleaving Enzyme 2A/C |
Verified Applications |
Immmunodepletion, Competition Assay |
Peptide Description |
Synthetic peptide taken within amino acid region 490-518 on human BACE2 protein. |
Accession # |
GenBank: AAQ89286 |
|
|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
|
|
Competition/Depletion assay |
|
|
|
Uniprot # |
|
Overview |
Responsible for the proteolytic processing of the amyloid precursor protein. Cleaves APP between 690 and 691 leading to the generation and extracellular release of beta-cleaved soluble APP and C-terminal fragment which is later released by gamma-secretase. |
Molecular Function |
Aspartic-type endopeptidase activity. |
Subcellular Location |
Endoplasmic reticulum, Endosome, Golgi apparatus; Membrane |
Expression |
Neurons within the hippocampus, frontal cortex and temporal cortex. Lower expression in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Also found in spinal cord, medulla oblongata, substan |
Structure |
Belongs to the peptidase A1 family. |
Alternative Nomenclature |
ALP 56 antibody ASP1 antibody ASP21 antibody Aspartic Like Protease 56kDa antibody Downs Syndrome Region Aspartic Protease antibody DRAP antibody Memapsin-1 antibody Membrane associated aspartic protease 1 antibody Theta-secretase antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
BACE-201AP | |||
|
BACE2-FITC | |||
|
BACE2-BIOTIN | |||
|
PC-BACE2 | |||
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