General Information |
|
Product |
DYRK1 Positive Control |
Description |
Western Blot Positive Control Dual specificity tyrosine-phosphorylation-regulated kinase 1A Antibody |
Verified Applications |
WB |
Immunogen |
Purified protein |
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|
Quantity |
5 Applications |
Volume |
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Form |
Western Blot Positive Control |
Purification Method |
Immobilized antigen affinity chromatography |
Storage |
-20⁰C for long term storage |
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Western Blot |
1:500 |
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Uniprot # |
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Overview |
May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3 |
Molecular Function |
Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase |
Subcellular Location |
Nucleus speckle |
Expression |
Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney. |
Structure |
The polyhistidine repeats act as targeting signals to nuclear speckles. |
Alternative Nomenclature |
Dual specificity tyrosine phosphorylation regulated kinase |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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DYRK1-101AP | |||
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DYRK1-BIOTIN | |||
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DYRK1-FITC | |||
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P-DYRK1 | |||
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