General Information |
|
Product |
5HT2A Receptor Peptide |
Description |
Antigenic Blocking Peptide 5-hydroxytryptamine receptor 2A Antibody |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Synthetic peptide taken within amino acid region 400-450 on human 5-hydroxytryptamine receptor 2A. |
Accession # |
NCBI: NP_000612 |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
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|
Competition/Depletion assay |
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Uniprot # |
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Overview |
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction. |
Molecular Function |
G-protein coupled receptor, Host cell receptor for virus entry, Receptor, Transducer |
Subcellular Location |
Cell Membrane, Cell projection |
Expression |
Detected in brain cortex. Detected in blood platelets. |
Structure |
The PDZ domain-binding motif is involved in the interaction with PATJ, CASK, APBA1, DLG1 and DLG4. |
Alternative Nomenclature |
5 HT2 receptor antibody 5 HT2A antibody 5 hydroxytryptamine receptor 2A antibody 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled antibody HTR 2A antibody HTR2 antibody serotonin 5-HT-2A receptor antibody Serotonin receptor 2A antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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5HT2A-101AP | |||
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5HT2A-BIOTIN | |||
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5HT2A-FITC | |||
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PC-5HT2A | |||
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