General Information
|
|
Product
|
CAMKII gamma Positive Control
|
Description
|
Western Blot Positive Control Calcium/calmodulin-dependent protein kinase type II subunit gamma Antibody
|
Verified Applications
|
WB
|
Physical Properties
|
|
Quantity
|
5 Applications
|
Volume
|
Inquire
|
Form
|
Western Blot Positive Control
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
Western Blot
|
1:500
|
Protein
|
Uniprot #
|
Q13555
|
Overview
|
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in sarcoplsamic reticulum Ca2+ transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.
|
Molecular Function
|
Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase
|
Subcellular Location
|
Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side
|
Expression
|
Skeletal muscle
|
Structure
|
CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other.
|
Alternative Nomenclature
|
Calcium/calmodulin dependent protein kinase type 1G antibody
CaM kinase I gamma antibody
CaM kinase IG antibody
CaMK-like CREB kinase III antibody
Camk1g antibody
CLICK III antibody
VWS1 antibody
|
|
|