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General Information
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Product
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BACE2 A/C Peptide
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Description
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Antigenic Blocking Peptide Beta Secretase beta-site APP cleaving Enzyme 2A/C
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Verified Applications
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Immmunodepletion, Competition Assay
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Peptide Description
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Synthetic peptide taken within amino acid region 490-518 on human BACE2 protein.
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Accession #
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GenBank: AAQ89286
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q9Y5Z0
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Overview
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Responsible for the proteolytic processing of the amyloid precursor protein. Cleaves APP between 690 and 691 leading to the generation and extracellular release of beta-cleaved soluble APP and C-terminal fragment which is later released by gamma-secretase.
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Molecular Function
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Aspartic-type endopeptidase activity.
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Subcellular Location
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Endoplasmic reticulum, Endosome, Golgi apparatus; Membrane
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Expression
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Neurons within the hippocampus, frontal cortex and temporal cortex. Lower expression in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Also found in spinal cord, medulla oblongata, substan
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Structure
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Belongs to the peptidase A1 family.
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Alternative Nomenclature
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ALP 56 antibody
ASP1 antibody
ASP21 antibody
Aspartic Like Protease 56kDa antibody
Downs Syndrome Region Aspartic Protease antibody
DRAP antibody
Memapsin-1 antibody
Membrane associated aspartic protease 1 antibody
Theta-secretase antibody
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BACE2 A/C Antibody
BACE2 A/C Antibody FITC
BACE2 A/C Antibody BIOTIN
BACE2 A/C Positive Control
