General Information |
|
Product |
Progesterone Receptor Antibody BIOTIN |
Description |
BIOTIN-Conjugated Progesterone Receptor Antibody N-epitope |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Cat, Human, Monkey, Pig |
Immunogen |
Synthetic peptide taken within amino acid region 320-370 on human Progesterone receptor protein. |
Accession # |
GenBank: AAD01587.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.50 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Determinant |
N-epitope |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunoprecipitation |
1:150 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. |
Molecular Function |
DNA binding; Enzyme binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; Steriod hormone receptor activity; Transcription regulation |
Subcellular Location |
Nucleus. Cytoplasm |
Structure |
Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and repesses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2. |
Alternative Nomenclature |
NR3C3 antibody Nuclear receptor subfamily 3 group C member 3 antibody PGR antibody PR antibody PR antibody PRA antibody PRB antibody Progesterone receptor antibody Progestin receptor form A antibody Progestin receptor form B antibody Progestin receptor form C antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-PGR.101 | |||
|
PGR-101AP | |||
|
PGR.101-FITC | |||
|
PC-PGR | |||
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