Ephrin Receptor A1 Antibody

Product no.: EPHAR1-101AP
$285.00


General Information

 

 

Product

 

Ephrin Receptor A1 Antibody

Description

Affinity Purified Ephrin type-A receptor 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 55-605 on human Ephrin type-A receptor 1.


Physical Properties

 

 

Quantity

 

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20C for long term storage


Application Protocol

 

ELISA

 

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500


Protein

 

Uniprot #

 

P21709

Overview

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

Molecular Function

ATP binding; protein kinase activity; protein kinase binding; transmembrane-ephrin receptor activity

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Expression

Overexpressed in several carcinomas.

Structure

Homodimer. Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1; regulates T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but independent of the kinase activity of EPHA

Alternative Nomenclature

EPH antibody

EPH receptor A1 antibody

Eph tyrosine kinase 1 antibody

EphA1 antibody

Ephrin receptor Eph A1 antibody

Ephrin type-A receptor 1 antibody

EPHT 1 antibody

Erythropoietin producing hepatoma amplified sequence antibody

Esk antibody

Esk antibody

hEpha1 antibody

MGC163163 antibody

Oncogene EPH antibody

Soluble EPHA1 variant 1 antibody

Soluble EPHA1 variant 2 antibody

Tyrosine protein kinase receptor EPH antibody

   

Protein information supplied by UniProt
 

 

Accessories

Product Note Status Price
Ephrin Receptor A1 Antibody FITC Ephrin Receptor A1 Antibody FITC
EPHAR1-FITC $375.00 *
Ephrin Receptor A1 Antibody BIOTIN Ephrin Receptor A1 Antibody BIOTIN
EPHAR1-BIOTIN $375.00 *
Ephrin Receptor A1 Blocking Peptide Ephrin Receptor A1 Blocking Peptide
P-EPHAR1 $155.00 *
Ephrin Receptor A1 Positive Control Ephrin Receptor A1 Positive Control
PC-EPHAR1 $200.00 *
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