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ADCY6 Antibody

Product no.: PAC-601AP

General Information
Product	ADCY6 Antibody
Description	Affinity Purified Adenylate cyclase type 6 Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Rat, Mouse
Immunogen	Synthetic peptide corresponding to N-terminal amino acids 13-27 of rat Particulate Adenylyl Cyclase 6 protein. Peptide was covalently modified and conjugated to KLH. Sequence: DERKTAWGERNGQKR
Accession #	GenBank: AAD29856.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.59 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:100-1:200
Dot Blot	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:100-1:200
Immunofluorescence	1:100-1:200
Immunohistochemistry	1:100-1:200
Western Blot	1:500
Protein
Uniprot #	Q03343
Overview	Membrane bound calcium-inhibitable adenylyl cyclase.
Molecular Function	Adenylate cyclase activity; cAMP biosynthesis; ATP-binding; Magnesium; Metal binding; Nucleotide-binding
Subcellular Location	Membrane; Multi-pass membrane protein; Cell projection; cilium
Structure	Part of a complex containing AKAP5, ADCY5, PDE4C, PKD2. Interacts with RAF1.
Alternative Nomenclature	AC6 ACVI ADCYB Adenylate cyclase 6 ATP pyrophosphate-lyase 6 Ca(2+) inhibitable adenylyl cyclase EC 4.6.1.1 KIAA0422

Protein information supplied by UniProt

Fabgennix ADCY6 Antibody has been used in 7 Publications

Kwon, Ronald Y. et al. “Primary Cilium-Dependent Mechanosensing Is Mediated by Adenylyl Cyclase 6 and Cyclic AMP in Bone Cells.” The FASEB Journal 24.8 (2010): 2859–2868. PMC2909282

Confocal Microscopy, Immunofluorescence, Western Blot; Human

Desch, Michael, et al. "PPARγ-dependent regulation of adenylate cyclase 6 amplifies the stimulatory effect of camp on renin gene expression." Molecular Endocrinology 24.11 (2010): 2139-2151.PMID20861226

Western Blot; Mouse

Bazhin, Alexandr V., et al. "Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4+ T cells." Molecular immunology 47.4 (2010): 678-684. PMID19939455

Western Blot; Mouse

Masyuk, Anatoliy I. et al. “Cholangiocyte Primary Cilia Are Chemosensory Organelles That Detect Biliary Nucleotides via P2Y12 Purinergic Receptors.”American Journal of Physiology - Gastrointestinal and Liver Physiology295.4 (2008): G725–G734. PMC2575915

Confocal Microscopy, Immunofluorescence; Rat

Masyuk, Anatoliy I. et al. “Cholangiocyte Cilia Detect Changes in Luminal Fluid Flow and Transmit Them into Intracellular Ca2+ and cAMP Signaling” Gastroenterology 131.3 (2006): 911–920. PMC1866168

Confocal Microscopy, Immunofluorescence; Rat

Grünberger, Christian, et al. "The Calcium Paradoxon of Renin Release Calcium Suppresses Renin Exocytosis by Inhibition of Calcium-Dependent Adenylate Cyclases AC5 and AC6." Circulation research 99.11 (2006): 1197-1206.

PMID17068292

Western Blot; Rat

Kolachala, Vasantha, et al. "Interferon-γ down-regulates adenosine 2b receptor-mediated signaling and short circuit current in the intestinal epithelia by inhibiting the expression of adenylate cyclase." Journal of Biological Chemistry 280.6 (2005): 4048-4057. PMID15550390

Western Blot; Human

Publishing research using PAC-601AP? Please let us know, we can cite the reference in this datasheet.

To view the Specification Sheet for ADCY6 Antibody, please click the link below:

ADCY6 Antibody | FabGennix

Customer ratings for ADCY6 Antibody

Number of ratings: 1
Average rating: 3

Average
from Verified Customer on 01/05/2021

Western blot using whole rat heart tissue lysate. Loaded 30 µg into 8% reduced denaturing gel. Blocked with 5% BSA for 1 hour at room temperature. 1/500 primary antibody dilution for 20 hours at 4°C in 5% BSA in TBST buffer.

All incoming ratings are posted by actual shop visitors / webshop customers and their content is checked by the operator by means of a visual inspection.

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ADCY6 Antibody FITC

PAC6-FITC

ADCY6 Antibody BIOTIN

PAC6-BIOTIN

ADCY6 Blocking Peptide

P-PAC6

ADCY6 Positive Control

PC-PAC6

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Browse these categories as well: G-Protein Coupled Receptors, Adenylate Cyclases, cAMP, Vision, Metabolism, Metabolism & Homeostasis, Cancer Research, Primaries

ADCY7 Antibody

Product no.: PAC-701AP

Description
Publications

General Information
Product	ADCY7 Antibody
Description	Affinity Purified Particulate Adenylate cyclase type 7 Antibody
Verified Applications	CM, ELISA, ICC/IF, IHC, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide corresponding to unique amino acid sequence on mouse Particulate Adenylyl Cyclase 7 protein.
Specificity	This antibody does not cross react with other Adenylate cyclases.
Accession #	NCBI: NP_031432.2
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.75 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:100-1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:100-1:200
Immunofluorescence	1:100-1:200
Immunohistochemistry	1:100-1:200
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	P51829
Overview	Membrane bound calcium-inhibitable adenylyl cyclase.
Molecular Function	Adenylate cyclase activity; cAMP biosynthesis; ATP-binding; Magnesium; Metal binding; Nucleotide-binding
Subcellular Location	Membrane; Multi-pass membrane
Expression	Heart, spleen and lung
Structure	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains.
Alternative Nomenclature	adenylate cyclase 7 antibody adenylyl cyclase antibody ATP pyrophosphate-lyase antibody KIAA0037 antibody

Protein information supplied by UniProt

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ADCY7 Antibody FITC

PAC7-FITC

ADCY7 Antibody BIOTIN

PAC7-BIOTIN

ADCY7 Blocking Peptide

P-PAC7

ADCY7 Positive Control

PC-PAC7

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Browse these categories as well: G-Protein Coupled Receptors, Adenylate Cyclases, Metabolism & Homeostasis, Metabolism, cAMP, Primaries

ADCY8 Antibody

Product no.: PAC-801AP

Description
Publications

General Information
Product	ADCY8 Antibody
Description	Affinity Purified Particulate adenylate cyclase 8 Antibody
Verified Applications	ELISA, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide corresponding to unique amino acid sequence on human Particulate Adenylyl Cyclase 8 protein.
Accession #	GenBank: AAZ13596.1
Quantity	100 µg
Volume	200 µl
Concentration	0.6 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Western Blot	1:500
Protein
Uniprot #	Q4F7X0
Overview	Involved in intracellular signal transduction and adenylate cyclase activity.
Molecular Function	Adenylate cyclase activity; cAMP biosynthesis; ATP-binding; Magnesium; Metal binding; Nucleotide-binding
Subcellular Location	Integral component of membrane
Structure	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Alternative Nomenclature	ADCY3 antibody ATP pyrophosphate-lyase 8 antibody Brain adenylate cyclase 8 antibody Ca(2+)/calmodulin activated adenylyl cyclase antibody HBAC1 antibody

Protein information supplied by UniProt

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ADCY8 Antibody FITC

PAC8-FITC

ADCY8 Antibody BIOTIN

PAC8-BIOTIN

ADCY8 Blocking Peptide

P-PAC8

ADCY8 Positive Control

PC-PAC8

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Browse these categories as well: Calcium Binding, Adenylate Cyclases, Neurotransmission, Metabolism, Metabolism & Homeostasis, cAMP, Primaries

ADCY9 Antibody

Product no.: PAC-901AP

Description
Publications

General Information
Product	ADCY9 Antibody Affinity Purified
Description	Affinity Purified Adenylate cyclase type 9 Antibody
Verified Applications	ELISA, WB; predicted to work with: CM, ICC, IHC, IF
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic Peptide taken within amino acid range 1300-1351 on human ADCY9 protein.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.75-1.20 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Western Blot	1:500
Protein
Uniprot #	O60503
Overview	Plays role in interplay between intracellular calcium and cAMP. Docking site for calcineurin.
Molecular Function	Adenylate cyclase activity; metal ion binding; ATP binding
Subcellular Location	Axon; dendrite; integral component of plasma membrane
Expression	Expressed in lung cells, airway smooth muscle
Structure	Adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains.
Alternative Nomenclature	ATP pyrophosphate lyase 9 antibody KIAA0520 antibody

Protein information supplied by UniProt

Synthetic Peptide taken within amino acid range 1300-1351 on human ADCY9 protein.

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ADCY9 Antibody FITC

PAC9-FITC

ADCY9 Antibody BIOTIN

PAC9-BIOTIN

ADCY9 Blocking Peptide

P-PAC9

ADCY9 Positive Control

PC-PAC9

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Browse these categories as well: G-Protein Coupled Receptors, Adenylate Cyclases, cAMP, Metabolism, Metabolism & Homeostasis, Primaries

Adenine Nucleotide Translocator 2 Antibody

Product no.: ANT2-201AP

General Information
Product	ANT2 Antibody
Description	Affinity Purified ADP/ATP Translocase 2 Antibody
Verified Applications	CM, ELISA, ICC/IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 150-200 on human ADP/ATP translocase 2. Sequence: AER EFR GLG DCL VKI YKS DGI KGL YQG FNV SVQ GII IYR AAY FGI YDT AK
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.68 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:100
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:100
Immunofluorescence	1:100
Immunohistochemistry	1:100
Immunoprecipitation	1:200
Western Blot	1:500. Molecular Weight: 33-36 kDa.
Protein
Uniprot #	P05141
Overview	Catalyzes exchange of cytoplasmic ADP with mitochondrial ATP across mitochondrial inner membrane. May also play role in chromosome segregation.
Molecular Function	Chromosome partition; Host-virus interaction; Transport
Subcellular Location	Mitochondrion inner membrane; multipass membrane protein
Structure	Homodimer, Component of MMXD complex.
Alternative Nomenclature	2F1 antibody AAC2 antibody Adenine nucleotide translocator 2 antibody ADP antibody ADP ATP carrier protein 2 antibody ANT2 antibody ATP carrier protein 2 antibody fibroblast isoform antibody SLC25A5 antibody Solute carrier family 25 member 5 antibody T2 antibody T3 antibody

Protein information supplied by UniProt

To view the Specification Sheet for ANT2 Antibody, please click the link below:

ANT2 Antibody | FabGennix

Customer ratings for Adenine Nucleotide Translocator 2 Antibody

Number of ratings: 1
Average rating: 5

Excellent in Western blot
from Anonymous on 12/09/2020

Got good results probing human ANT2 with this antibody at 1:500 dilution

All incoming ratings are posted by actual shop visitors / webshop customers and their content is checked by the operator by means of a visual inspection.

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Adenine Nucleotide Translocator 2 Antibody FITC

ANT2-FITC

Adenine Nucleotide Translocator 2 Antibody BIOTIN

ANT2-BIOTIN

Adenine Nucleotide Translocator 2 Blocking Peptide

P-ANT2

Adenine Nucleotide Translocator 2 Positive Control

PC-ANT2

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Browse these categories as well: Mitochondria, Metabolism, Metabolism & Homeostasis, Tags and Cell Markers, Cancer Research, Primaries

Adenylate cyclase 1 Antibody

Product no.: PAC-101AP

General Information
Product	Adenylate Cyclase 1 Antibody
Verified Applications	ELISA, IP, WB
Host	Rabbit
Species Cross Reactivity	Mouse, Rabbit, Rat
Immunogen	Synthetic peptide corresponding to conserved sequence at or near C terminal end of protein that is unique to rat/mouse Adenylyl Cyclase 1 protein.
Accession #	GenBank: AAC29478
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.55- 0.72 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
ELISA	1:10,000
Immunoprecipitation	1:200
Western Blot	1:500. Detects a band 127-10 kDa
Protein
Uniprot #	O88444
Overview	This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina
Molecular Function	ATP-binding, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding
Subcellular Location	Membrane; Multi-pass membrane protein. Cytoplasm
Expression	Expressed throughout inner ear development. Brain, retina and adrenal medulla.
Structure	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains
Alternative Nomenclature	3'5' cyclic AMP synthetase antibody ADCY1 antibody adenyl cyclase antibody Adenylate cyclase 1 antibody ATP pyrophosphate lyase antibody Brain adenylate cyclase 1 antibody Ca(2+)/calmodulin activated adenylyl cyclase antibody EC 4.6.1.1 antibody

Protein information supplied by UniProt

Fabgennix Adenylate cyclase 1 Antibody has been used in 3 Publications

Nakamura, Akio, Makoto Miyagawa, and Yukishige Yanagawa. "Modulation of 11β-hydroxysteroid dehydrogenase 1 by β2-adrenoceptor in the ischaemia-reperfused rat kidney." Nephrology Dialysis Transplantation 27.9 (2012): 3456-3464. PMID22187316

Western Blot; Rat

Nakamura, Akio, Ryo Niimi, and Yukishige Yanagawa. "Protection from sepsis-induced acute renal failure by adenoviral-mediated gene transfer of β2-adrenoceptor†." Nephrology Dialysis Transplantation (2009): gfp561. PMID19887504

Western Blot; Rat

Younes, Antoine et al. “Ca2+-Stimulated Basal Adenylyl Cyclase Activity Localization in Membrane Lipid Microdomains of Cardiac Sinoatrial Nodal Pacemaker Cells.” The Journal of Biological Chemistry 283.21 (2008): 14461–14468. PMC2386925

Dot Blot; Rabbit

Publishing research using PAC-101AP? Please let us know, we can cite the reference in this datasheet.

Has the homology of AC1 with other AC family members been tested or determined?
1. Yes the cross reactivity to PAC-1-9 have been tested and found to be non-reactive. No other antibody cross react with non-homologus protein.

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Adenylate cyclase 1 Antibody FITC

PAC1-FITC

Adenylate cyclase 1 Antibody BIOTIN

PAC1-BIOTIN

Adenylate cyclase 1 Blocking Peptide

P-PAC1

Adenylate cyclase 1 Positive Control

PC-PAC1

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Browse these categories as well: G-Protein Coupled Receptors, Adenylate Cyclases, Primaries, Neurotransmission, Cancer Research, Metabolism, Metabolism & Homeostasis, cAMP

Adenylate Cyclase 10 Antibody

Product no.: SAC10-101AP

Description

General Information
Product	Soluble Adenylate Cyclase 10 Antibody
Description	Affinity Purified Bicarbonate activated soluble adenylate cyclase 10 Antibody
Verified Applications	ELISA, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Gorilla, Rat
Immunogen	Synthetic peptide taken within amino acid region 200-250 on mouse Adenylate Cyclase type 10 protein.
Accession #	NCBI: NP_766617.2
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.55-0.75 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunoprecipitation	1:150
Western Blot	1:500
Protein
Uniprot #	Q8C0T9
Overview	Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor.
Molecular Function	Adenylate cyclase activity; ATP binding; Magnesium ion binding; Manganese ion binding
Subcellular Location	Cell membrane, Cytoplasm, Cytoskeleton, Membrane
Expression	Expressed in testis.
Structure	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains.
Alternative Nomenclature	3',5'-cyclic AMP synthetase antibody Adenylate cyclase 10 (soluble) antibody AH related protein antibody ATP pyrophosphate-lyase antibody Germ cell soluble adenylyl cyclase antibody HCA2 antibody hsAC antibody hypercalciuria absorptive antibody SAC antibody SACI antibody Sacy antibody Soluble adenylyl cyclase antibody Testicular soluble adenylyl cyclase antibody

Protein information supplied by UniProt

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Adenylate Cyclase 10 Antibody FITC

SAC10-FITC

Adenylate Cyclase 10 Antibody BIOTIN

SAC10-BIOTIN

Adenylate Cyclase 10 Blocking Peptide

P-SAC10

Adenylate Cyclase 10 Positive Control

PC-SAC10

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Soluble Adenylate Cyclase 1 Antibody

SAC-112AP

Soluble Adenylate Cyclase 1 Antibody

SAC-121AP

Soluble Adenylate Cyclase 1 Antibody

Browse these categories as well: cAMP, Energy Metabolism, Metabolism & Homeostasis, Metabolism, Primaries

Adiponectin Antibody

Product no.: ADPN-101AP

Description

General Information
Product	Adiponectin Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Pig
Immunogen	Synthetic peptide taken within amino acid region 150-243 on pig Adiponectin protein.
Accession #	GenBank: AY589691
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.64-0.65 µg/µl in antibody stabilization buffer
Immunoglobulin	IgG
Form	Affinity Purified
Purification Method	Immobilized antigen affinity chromatography
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
ELISA	1:10,000
Immunohistochemistry	1:50-1:150
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	Q69907
Overview	Involved in brown fat cell differentiation, responses to drugs, detection of oxidative stress glucose homeostasis and fatty acid oxidation. Invovled in regulation of DNA biosynthetic processes.
Molecular Function	Hormone activity; receptor binding
Subcellular Location	Cell periphery; collagen trimer; extracellular space; cell surface; endoplasmic reticulum; perinuclear region of cytoplasm
Expression	Secreted
Alternative Nomenclature	30 kDa adipocyte complement related protein antibody ACDC antibody ACRP 30 antibody Adipocyte antibody Adipocyte C1q and collagen domain containing protein antibody Adipocyte complement related 30 kDa protein antibody adipocyte-specific secretory protein antibody Adiponectin antibody adiponectin, C1Q and collagen domain containing antibody AdipoQ antibody Adipose most abundant gene transcript 1 antibody Adipose specific collagen like factor antibody ADIPQTL1 antibody ADPN antibody APM 1 antibody C1q and collagen domain-containing protein antibody GBP 28 antibody Gelatin binding protein antibody Gelatin binding protein 28 antibody

Protein information supplied by UniProt.

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Adiponectin Antibody FITC

ADPN-FITC

Adiponectin Antibody BIOTIN

ADPN-BIOTIN

Adiponectin Blocking Peptide

P-ADPN

Adiponectin Positive Control

PC-ADPN

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Browse these categories as well: Oxidative Stress, Cell Differentiation, Regulation, DNA / RNA, Lipids, Cardiology, Cancer Research, Obesity, Diabetes, Primaries

AGE Antibody

Product no.: AGE-101AP

Description

General Information
Product	AGE Antibody
Description	Affinity Purified Advance Glycated Endproduct Antibody
Verified Applications	ELISA, WB
Host	Rabbit
Species Cross Reactivity	Bovine, Human, Monkey, Panda
Immunogen	Purified glycated ribonuclease corresponding to AGE. Glycated ribonuclease (RNase) prepared by incubating RNase with glucose at 37⁰C for several months.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.55 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Western Blot	1:500
Protein
Overview	Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators.
Molecular Function	Inflammatory Response
Subcellular Location	Isoform 1 : Cell membrane; Single-pass type I membrane protein Isoform 2 : Secreted Isoform 10 : Cell membrane 1 Publication; Single-pass type I membrane protein
Expression	Endothelial cells.
Structure	Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked.
Alternative Nomenclature	Advanced glycation end products antibody AGEs antibody

Protein information supplied by UniProt

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AGE Antibody FITC

AGE-FITC

AGE Antibody BIOTIN

AGE-BIOTIN

AGE Blocking Peptide

P-AGE

AGE Positive Control

PC-AGE

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Browse these categories as well: Autoimmune, Metabolism & Homeostasis, Metabolism, Atherosclerosis, Lipids, Diabetes, Cancer Research, Primaries

AIM2 Antibody

Product no.: AIM2-201AP

Description

General Information
Product	AIM2 Antibody
Description	Affinity Purified Interferon-inducible protein AIM2 Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse
Immunogen	Synthetic peptide taken within amino acid region 240-340 on human AIM2 protein.
Accession #	NCBI: NP_004824
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.58 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunohistochemistry	1:50-1:100
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	O14862
Overview	Innate immune response recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Molecular Function	Apoptosis, Immunity, Inflammatory response, Innate Immunity
Expression	Expressed in spleen, small intestine, peripheral blood leukocytes and testis.
Structure	Self-associates; forms homodimers in response to cytosolic dsDNA and the dsDNA serves as oligomerization platform.
Alternative Nomenclature	Absent in melanoma 2 antibody PYHIN4 antibody

Protein information supplied by UniProt