General Information

Product

BMP2 Antibody

Description

Affinity Purified Bone morphogenetic protein 2 Antibody

Verified Applications

Dot blot, ELISA, WB, ICC/IF, IHC-Fr, IHC-P, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide corresponding to Mouse BMP2 amino acid region 45-60 conjugated to Keyhole Limpet Haemocyanin (KLH).

Sequence:

SEDVLSEFELRLLSMF

Accession #

NCBI: NP_031579

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.73 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

Dot Blot

1:2,000

ELISA

1:2,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200-1:500

Immunoprecipitation

1:200

Western Blot

1:500-1:1000. Detects band of approximately 45 kDa

Protein

Uniprot #

P21274

Overview

Induces cartilage and bone formation

Molecular Function

Chondrogenesis; Differentiation; Osteogenisis; Cytokine; Developmental protein, Growth Factor

Subcellular Location

Secreted

Structure

Homodimer; Disulfide linked.

Alternative Nomenclature

BDA2 antibody

BMP 2 antibody

BMP2A antibody

Bone morphogenetic protein 2 antibody

Bone morphogenetic protein 2A antibody

General Information

Product

BMP4 Antibody

Description

Affinity Purified Bone morphogenetic protein 4 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 184-197 on rat BMP4 protein, peptide was covalently modified.

Sequence:

VMKPPAPGHLIC

Accession #

NCBI:  NP_036959

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Dot Blot

1:2,000

ELISA

1:2,000

Western Blot

1:500

Protein

Uniprot #

Q9AYU9

Overview

Invovled in chemoattractant activity and heparin binding

Molecular Function

Growth Factors

Subcellular Location

Extracellular space; Secreted

Structure

Belongs to the TGF-beta family

Alternative Nomenclature

BMP 2B antibody

Bone morphogenetic protein 2B antibody

DVR4 antibody

MCOPS6 antibody

OFC11 antibody

ZYME antibody

General Information

Product

BMP8 Antibody

Description

Affinity Purified Bone morphogenetic protein 8 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 160-200 on human BMP8 protein

Accession #

NCBI:  CAB75681

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.57-0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

DB

1:2,000

ELISA

1:2,000

Western Blot

1:500-1:1,000

Protein

Uniprot #

P34820

Overview

Induces cartilage and bone formation.

Molecular Function

Chondrogenesis; Differentiation; Osteogenesis

Subcellular Location

Secreted

Structure

Homodimer; Disfulfide-linked

Alternative Nomenclature

OP 2 antibody

Osteogenic protein 2 antibody BMP-8 antibody

dJ118J21.1 (bone morphogenetic protein 8 (osteogenic protein 2)) antibody

Osteogenic protein 2 antibody

General Information

Product

CXCR4 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 15-65 on CXCR4 protein.

Accession #

GenBank:  CAA12166

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P61073

Overview

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Molecular Function

Host-virus Interaction

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome

Expression

Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.

Structure

Monomer. Can form dimers.

Alternative Nomenclature

C-X-C chemokine receptor type 4 antibody

CD184 antibody

Chemokine CXC Motif Receptor 4 antibody

CXCR4 antibody

D2S201E antibody

FB22 antibody

Fusin antibody

HM89 antibody

HSY3RR antibody

LAP 3 antibody

LCR1 antibody

LESTR antibody

Leukocyte derived seven transmembrane domain receptor antibody

Lipopolysaccharide associated protein 3 antibody

Neuropeptide Y receptor Y3 antibody

NPY3R antibody

NPYR antibody

NPYRL antibody

Probable G protein coupled receptor lcr1 homolog antibody

SDF 1 receptor antibody

Stromal cell derived factor 1 receptor antibody

WHIM antibody

General Information

Product

EAAT1 Antibody

Description

Affinity Purified Excitatory Amino Acid Transporter 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide corresponding to C terminal amino acids 480-543 of Mouse EAAT1 protein. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using heterobifunctional cross linker for immunogen preparation.

Sequence:

KPYQLIAQDNEPEKPVADSETK

Accession #

NCBI:  NP_683740.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.61 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P56564

Overview

Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

Molecular Function

high-affinity glutamate transmembrane transporter activity;sodium:dicarboxylate symporter activity

Subcellular Location

plasma membrane; cell surface; fibril;neuronal cell body

Expression

Purkinje cell layer in cerebellum,lung,spleen, skeletal muscle and testis.

Structure

Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily has a Transmembrane helix.

Alternative Nomenclature

EA6 antibody

EAAT1 antibody

Excitatory amino acid transporter 1 antibody

FLJ25094 antibody

GLAST antibody

Glial high affinity glutamate transporter antibody

glutamate/aspartate transporter, high affinity, sodium-dependent antibody

High affinity neuronal glutamate transporter antibody

Slc1a3 antibody

Sodium dependent glutamate/aspartate transporter antibody

Solute carrier family 1 member 3 antibody

General Information

Product

DDIT3 Antibody

Description

Affinity Purified DNA damage-inducible transcript 3 protein Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 60-160 on human GADD153 protein

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.57-0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P35638

Overview

Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes.

Molecular Function

Activator, Repressor, DNA binding

Subcellular Location

Cytoplasm, Nucleus

Structure

Heterodimer. Interacts with TCF7L2/TCF4, EP300/P300, HDAC1, HDAC5 and HDAC6. Interacts with TRIB3 which blocks its association with EP300/P300. Interacts with FOXO3, CEBPB and ATF4.

Alternative Nomenclature

C/EBP homologous protein antibody

C/EBP zeta antibody

CCAAT/enhancer binding protein homologous protein antibody

CEBPZ antibody

CHOP 10 antibody

DDIT3 antibody

DNA Damage Inducible Transcript 3 antibody

GADD153 antibody

Growth Arrest and DNA Damage Inducible Protein 153 antibody

MGC4154 antibody

General Information

Product

MSX1 Antibody 

Description

Affinity Purified MSX1 protein Antibody

Verified Applications

DB, ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide:

DEEGAKPKVSPSLLPFSVE

corresponding to amino acids 46-64 of Mouse Msx1 protein. The peptide was post synthetically modified and conjugated to KLH using hetero bifunctional cross linker for immunization of rabbits. 

Accession #

GenBank: AAH67353.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000-1:50,000

ELISA

1:20,000-1:50,000

Western Blot

1:500-1:750

Protein

Uniprot #

P28360

Overview

Acts as a transcriptional repressor;play a role in limb-pattern formation,cranofacial development and odontogenesis

Molecular Function

Developmental protein, Repressor

Subcellular Location

Nucleus

Expression

Expressed in the developing nail bed mesenchyme.

Structure

Belongs to the Msh homeobox family

Alternative Nomenclature

AA675338 antibody

AI324650 antibody

Homeobox protein Hox-7 antibody

Homeobox protein MSX 1 antibody

HOX 7 antibody

HYD 1 antibody

msh (Drosophila) homeo box homolog 1

Msh antibody

MSX 1 antibody

OFC5 antibody

STHAG1 antibody

General Information

Product

PCSK9 Antibody

Description

Affinity Purified Proprotein convertase subtilisin/kexin type 9 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 30-60 on the NARC1 protein.

Accession #

NCBI:  NP_705793.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.85-1.25 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

Q80W65

Overview

Crucial player in the regulation of plasma cholesterol homeostasis

Molecular Function

Hydrolase, Protease, Serine protease

Subcellular Location

Cytoplasm, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Secreted

Expression

Hepatocytes, kidney mesenchymal cells, intestinal ileum, colon epithelia and embryonic brain telencephalon neurons.

Structure

Monomer. Can self-associate to form dimers and higher multimers,Belongs to the peptidase S8 family

Alternative Nomenclature

Convertase subtilisin/kexin type 9 preproprotein antibody

FH3 antibody

HCHOLA3 antibody

LDLCQ1 antibody

NARC 1 antibody

PC 9 antibody

PCSK9 antibody

PSEC0052 antibody

General Information

Product

p75 NGF Receptor Antibody

Description

Affinity Purified p75 neurotrophin receptor a-2 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Immunogen

Synthetic peptide corresponding to unique N-terminus amino acid sequence on P-75NTR protein.

Accession #

GenBank: AAD51031.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.95 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9PRG7

Molecular Function

Receptor

Alternative Nomenclature

CD271 antibody

CD271 antigen antibody

Gp80 LNGFR antibody

Low affinity nerve growth factor receptor antibody

Nerve growth factor receptor antibody

NGF receptor antibody

NGFR antibody

p75 ICD antibody

p75 Neurotrophin receptor antibody

p75 NTR antibody

TNFR Superfamily Member 16 antibody

TNFRSF16 antibody

General Information

Product

PAX3 Antibody

Description

Affinity Purified Paired Box Protein Pax-3 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on PAX3 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

.64-.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P23760

Overview

Is a transcription factor that may regulate cell proliferation, migration and apoptosis.  Plays a role in neural development and myogenesis.

Molecular Function

Developmental protein, chromatin binding, sequence-specific DNA binding

Subcellular Location

Nucleus

Structure

Capable of binding to DNA as a homodimer or a heterodimer with PAX7.  Interacts with DAXX and TBX18.

Alternative Nomenclature

CDHS antibody

HUP 2 antibody

MGC120381 antibody

MGC120382 antibody

MGC120383 antibody

MGC120384 antibody

MGC134778 antibody

Paired box 3 antibody

paired box homeotic gene 3 antibody

paired domain gene 3 antibody

PAX 3 antibody

PAX3/FKHR fusion gene antibody

Waardenburg syndrome 1 antibody

WS 1 antibody

WS3 antibody