General Information |
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Product |
PDE2A Antibody BIOTIN-Conjugated |
Description |
BIOTIN-Conjugated Phosphodiesterase 2A, cGMP-stimulated Antibody N-epitope |
Verified Applications |
CM, ELISA, ICC/IF, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide corresponding to unique N-terminal amino acid sequence on PDE2A gene. |
Specificity | This antibody will label PDE2A1, PDE2A2, PDE2A3 and PDE2A4 variants. |
Accession # |
GenBank: EAW74861.1 |
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|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.7 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Determinant |
N-epitope |
Storage |
-20⁰C for long term storage |
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|
Confocal Microscopy |
1:250-1:1,000 |
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunocytochemistry |
1:250-1:1,000 |
Immunofluorescence |
1:150-1:1,000 |
Immunohistochemistry |
1:250-1:1,000 |
Immunoprecipitation |
1:200 |
Western Blot |
1:250-1:1,000 |
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Uniprot # |
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Overview |
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. |
Molecular Function |
Hydrolase, cAMP, cGMP, Metal-binding, Angiogenesis |
Subcellular Location |
Multi-pass membrane protein |
Expression |
bundant in adipose tissues. |
Structure |
Interacts with PIK3CG (By similarity). Interacts with RAPGEF3 and PIK3R6. |
Alternative Nomenclature |
5''-cyclic phosphodiesterase antibody cGMP dependent 3'5' cyclic phosphodiesterase antibody cGMP stimulated phosphodiesterase 1 antibody cGMP stimulated phosphodiesterase 4 antibody cGMP-dependent 3'' antibody CGS PDE antibody Cyclic GMP stimulated phosphodiesterase antibody PDE 2A antibody PDE 2A1 antibody PDE 2A4 antibody PDE2A antibody Phosphodiesterase 2A cGMP stimulated antibody |
Protein information supplied by UniProt
Fabgennix PDE2A Antibody has been used in 34 Publications |
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Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015). PMID25578602
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Immunohistochemistry; Human |
Kedia, George T., et al. "Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Male Urethra." Urology (2015). PMID25704994
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Immunohistochemistry, Western Blot; Human |
Rajagopal, Senthilkumar, et al. "Cytokine-Induced S-Nitrosylation of Soluble Guanylyl Cyclase and Expression of Phosphodiesterase 1A Contribute to Dysfunction of Longitudinal Smooth Muscle Relaxation." Journal of Pharmacology and Experimental Therapeutics 352.3 (2015): 509-518. PMID25550199
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Western Blot; Mouse |
Rentsendorj, Otgonchimeg, Franco R. D'Alessio, and David B. Pearse. "Phosphodiesterase 2A is a major negative regulator of iNOS expression in lipopolysaccharide-treated mouse alveolar macrophages." Journal of leukocyte biology 96.5 (2014): 907-915. PMID25063878
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Western Blot; Mouse |
Zhai, Kui, et al. "Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms." Cellular signalling 26.5 (2014): 1001-1010. PMID24463006
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Western Blot; Rat |
Yougbaré, Issaka, et al. "Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842.7 (2014): 916-926. PMID24631654
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Immunohistochemistry, Western Blot; Mouse |
Hiramoto, Kenichi, et al. "Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells." Cellular signalling 26.9 (2014): 1807-1817. PMID24705027
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Western Blot; Human |
MORITA, HIROSHI et al. “Characterization of Phosphodiesterase 2A in Human Malignant Melanoma PMP Cells.” Oncology Reports 29.4 (2013): 1275–1284. PMC3621658
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Western Blot; Human |
Brechbühl, Julien, Fabian Moine, and Marie-Christine Broillet. “Mouse Grueneberg Ganglion Neurons Share Molecular and Functional Features withC. Elegans Amphid Neurons.” Frontiers in Behavioral Neuroscience 7 (2013): 193. PMC3856774
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Immunohistochemistry; Mouse |
Matsuo, Tomohiko, et al. "The wiring of Grueneberg ganglion axons is dependent on neuropilin 1." Development 139.15 (2012): 2783-2791. PMID22745317
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Immunohistochemistry; Mouse |
For a complete listing of FabGennix PDE2A publications, please click here.
Publishing research using PD2A-101AP? Please let us know, we can cite the reference in this datasheet.
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