General Information |
|
Product |
PDE7A Antibody BIOTIN-Conjugated |
Description |
BIOTIN-Conjugated cAMP-specific cyclic nucleotide phosphodiesterase PDE7A3 Antibody |
Verified Applications |
CM, ELISA, ICC, IF, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic cyclic peptide common to all PDE7A variants. |
Specificity | This antibody is specific for PDE7A variants and will not cross-react with PDE7B or other PDE family members. |
Accession # |
GenBank: AAK57640.1 |
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|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
Confocal Microscopy |
1:100-1:250 |
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunocytochemistry |
1:100-1:250 |
Immunofluorescence |
1:100-1:250 |
Immunohistochemistry |
1:100-1:250 |
Immunoprecipitation |
1:250 |
Western Blot |
1:500 |
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|
Uniprot # |
|
Overview |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. |
Molecular Function |
3', 5' -cyclic-AMP phosphodiesterase activity |
Subcellular Location |
Isoform PDE7A1 : Cytoplasm › cytosol, Isoform PDE7A2: Cytoplasm |
Expression |
PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart. |
Structure |
Interacts with CBFA2T3 |
Alternative Nomenclature |
HCP 1 antibody P2A antibody PDE 7 antibody PDE 7A antibody PDE1/PDE2 yeast human complement of antibody Phosphodiesterase 7A antibody Phosphodiesterase isozyme 7 antibody Rolipram insensitive phosphodiesterase type 7 antibody TM22 antibody |
Protein information supplied by UniProt
Fabgennix PDE7A Antibody has been used in 3 Publications |
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Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015). PMID25578602
|
Immunohistochemistry; Human |
Ong, WK et al. “The Role of the PDE4D cAMP Phosphodiesterase in the Regulation of Glucagon-Like Peptide-1 Release.” British Journal of Pharmacology 157.4 (2009): 633–644. PMC2707975
|
Immunoprecipitation, Immunofluorescence, Western Blot; Human |
Zhang, Lingzhi et al. “Cyclic Nucleotide Phosphodiesterase Profiling Reveals Increased Expression of Phosphodiesterase 7B in Chronic Lymphocytic Leukemia.” Proceedings of the National Academy of Sciences of the United States of America 105.49 (2008): 19532–19537. PMC2614795
|
Western Blot; Human |
Publishing research using PD7A-101AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-PD7A | |||
|
PD7A-101AP | |||
|
PD7A-FITC | |||
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PC-PD7A | |||
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