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PDE4B Antibody

Product no.: PD4B-201AP

$320.00

General Information
Product	PDE4B Antibody
Description	Affinity Purified cAMP-specific 3',5'-cyclic phosphodiesterase 4B Antibody N-epitope
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide common to all PDE4B subtypes taken near N-terminal
Specificity	This antibody detects all PDE4B proteins, including PDE4B1, PDE4B2, PDE4B3, and a 66 kDa PDE4B variant. It does not cross-react with other PDE family members such as PDE4A, PDE4C. PD4B-201AP may have minor crossreactivity to PDE4D. Antibody PD4B-212AP does not have any cross reactivity with any other PDE family members other than: PDE4B1, PDE4B2, PDE4B3, PDE4B4.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.68 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Determinant	N-epitope
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:250
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:250
Immunofluorescence	1:250
Immunohistochemistry	1:250
Immunoprecipitation	1:350
Western Blot	1:500-1:1,000
Protein
Uniprot #	Q07343
Overview	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
Molecular Function	Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding
Expression	Expressed in brain, heart, lung and skeletal muscle.
Alternative Nomenclature	5''-cyclic phosphodiesterase 4B antibody cAMP-specific 3'' antibody cAMP-specific 3',5'-cyclic phosphodiesterase 4B antibody DPDE4 antibody dunce-like phosphodiesterase E4 antibody MGC126529 antibody PDE 4B antibody PDE IVB antibody PDE32 antibody PDE4B5 antibody PDEIVB antibody Phosphodiesterase 4B antibody Phosphodiesterase-4B cAMP-specific (dunce (Drosophila)-homolog) antibody

Protein information supplied by UniProt

Fabgennix PDE4B Antibody has been used in 42 Publications
Kedia, George T., et al. "Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Male Urethra." Urology (2015). PMID25704994	Immunofluorescence, Western Blot; *Human*
Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015). PMID25578602	Immunohistochemistry; *Human*
Guo, Jiejie, et al. "Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice." Neuroscience 263 (2014): 1-14. PMID24434771	Western Blot; *Mouse*
Zhai, Kui, et al. "Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms." Cellular signalling 26.5 (2014): 1001-1010.PMID24463006	Western Blot; *Human*
Hiramoto, Kenichi, et al. "Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells." Cellular signalling 26.9 (2014): 1807-1817. PMID24705027	Western Blot; *Rat*
Wang, Zhen-Zhen et al. “RNA Interference-Mediated Phosphodiesterase 4D Splice Variants Knock-down in the Prefrontal Cortex Produces Antidepressant-Like and Cognition-Enhancing Effects.” British Journal of Pharmacology 168.4 (2013): 1001–1014. PMID23003922	Western Blot; *Mouse*
Sanabra, Cristina, Emily M. Johansson, and Guadalupe Mengod. "Critical role for PDE4 subfamilies in the development of experimental autoimmune encephalomyelitis." Journal of chemical neuroanatomy 47 (2013): 96-105. PMID23274837	Immunohistochemistry; *Mouse*
Yougbaré, Issaka, et al. "NCS 613 Exhibits Anti-Inflammatory Effects On Pbmcs From Lupus Patients By Inhibiting P38 MAPK And NF-Κb Signalling Pathways While Reducing Proinflammatory Cytokine Production." Canadian Journal Of Physiology & Pharmacology 91.5 (2013): 353-361. PMID23656347	Immunocytochemistry, Western Blot; *Human*
Haque, Mohammed Z., Paulo S. Caceres, and Pablo A. Ortiz. “β-Adrenergic Receptor Stimulation Increases Surface NKCC2 Expression in Rat Thick Ascending Limbs in a Process Inhibited by Phosphodiesterase 4.” American Journal of Physiology - Renal Physiology 303.9 (2012): F1307–F1314. PMC3518189	Western Blot; *Rat*
Johansson, Emily M., Cristina Sanabra, and Guadalupe Mengod. "Sex‐related differences of cAMP‐specific PDE4B3 mRNA in oligodendrocytes following systemic inflammation." Glia 60.12 (2012): 1815-1825. PMID22848007	Western Blot; *Mouse*

For a complete listing of FabGennix PDE4B publications, please click here.

Publishing research using PD4B-201AP? Please let us know, we can cite the reference in this datasheet.

Could you please provide me with the immunogen sequence for Anti-PDE4B antibody (PD4B-201AP)

If it is not possible to provide me with the immunogen sequence itself, could you please send me the amino acid range that the immunogen is from?

Our PDE4B Antibody (PD4B-201AP), was developed using a recombinant fragment for PDE4B comprising of both UCR1 and UCR2 regions of the long-form variants. The antibody labels all PDE4B variants and has minor cross reactivity to PDE4D. We also have another C-terminal epitope PDE4B selective antibody (PD4B-212AP) that has no cross reactivity to any other PDE4 family members except PDE4B1, PDE4B2, PDE4B3, and PDE4B4.

In addition to these two, we also have antibodies that are selective for PDE4B subtype variants (PDE4B1, PDE4B2, PDE4B3, and PDE4B4) for studying individual variants of the PDE4B family members.

Customer ratings for PDE4B Antibody

Number of ratings: 1
Average rating: 4

Good for western blot
from Anonymous on 12/09/2020

Great results in western blot using rat cell lysate (Mesangial cells). 1/5000 primary antibody dilution for 8 hours.

All incoming ratings are posted by actual shop visitors / webshop customers and their content is checked by the operator by means of a visual inspection.

Accessories

Product

Note

Status

Price

PDE4B Antibody FITC

PD4B-FITC

$375.00 *

PDE4B Antibody BIOTIN

PD4B-BIOTIN

$375.00 *

PDE4B Blocking Peptide

P-PD4B

$155.00 *

PDE4B Positive Control

PC-PD4B

$220.00 *

PD4B-212AP PDE4B Antibody $320.00 *	PD4B1-261AP PDE4B1 Antibody $320.00 *	PD4B2-251AP PDE4B2 Antibody $320.00 *
PD4B3-221AP PDE4B3 Antibody $320.00 *	PD4B4-231AP PDE4B4 Antibody $320.00 *

PDE4A Antibody $375.00 *	PDE4A5 Antibody $320.00 *	PDE4B1 Antibody $320.00 *
PDE4A1 Antibody $320.00 *	PDE4A10 Antibody $320.00 *

General Information
Product	PDE4D9 Antibody
Description	Affinity Purified Phosphodiesterase 4D9 Antibody
Verified Applications	ELISA, IP, WB
Host	Rabbit
Species Cross Reactivity	Chicken, Mouse, Rat
Immunogen	Synthetic peptide corresponding to unique amino acid sequence on PDE4D9 variant gene.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.2 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunoprecipitation	1:150
Western Blot	1:500-1:1,000
Protein
Overview	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Molecular Function	Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding
Subcellular Location	Apical cell membrane, Cytoplasm, Membrane
Expression	Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.
Structure	Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protei
Alternative Nomenclature	cAMP specific 3',5' cyclic phosphodiesterase 4D antibody DKFZp686M11213 antibody 5''-cyclic phosphodiesterase 4D antibody cAMP specific phosphodiesterase 4D antibody cAMP specific phosphodiesterase PDE4D antibody DPDE 3 antibody Dunce like phosphodiesterase E3 antibody FLJ97311 antibody HSPDE4D antibody PDE 43 antibody PDE4DN2 antibody Phosphodiesterase E3 dunce homolog Drosophila antibody STRK1 antibody

PD4D2-421AP PDE4D2 Antibody $285.00 *	PPD4-450AP Phospho-PDE4D ERK site Antibody $375.00 *	PD4D4-441AP PDE4D4 Antibody $320.00 *
PD4D4-442AP PDE4D4 Antibody $320.00 *

General Information
Product	Pan PDE6 Alpha Antibody
Description	Affinity Purified Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic cyclic peptide common to all PDE6 Alpha variants
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.50-0.75 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:250
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:250
Immunofluorescence	1:250
Immunohistochemistry	1:250
Immunoprecipitation	1:250
Western Blot	1:500
Protein
Uniprot #	P51160
Molecular Function	Hydrolase, 3',5'-cyclic-GMP phosphodiesterase activity, cGMP binding
Subcellular Location	Cell membrane; Lipid-anchor; Cytoplasmic side
Structure	Composed of two alpha' subunits that are associated with 3 smaller proteins of 11, 13, and 15 kDa.
Alternative Nomenclature	5''-cyclic phosphodiesterase subunit alpha antibody CGPR A antibody GMP PDE alpha antibody PDE 6 alpha antibody PDE V B1 antibody PDEA antibody Phosphodiesterase 6 alpha antibody Retinal Rod Photoreceptor cGMP Rod cGMP specific 3' 5' cyclic phosphodiesterase alpha subunit antibody

General Information
Product	PDE6 Beta Antibody
Description	Affinity Purified Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Antibody
Verified Applications	ELISA, CM, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Bovine, Human, Mouse, Pig, Rat
Immunogen	Synthetic cyclic petide common to all PDE6 Beta variants
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.5 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:200
Immunofluorescence	1:200
Immunohistochemistry	1:200
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	P35913
Overview	This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme.
Molecular Function	Hydrolase, 3', 5' -cyclic-AMP phosphodiesterase activity
Subcellular Location	Membrane; lipid anchor
Structure	Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.
Alternative Nomenclature	5''-cyclic phosphodiesterase subunit beta antibody Congenital stationary night blindness 3 autosomal dominant antibody CSNB 3 antibody CSNBAD2 antibody DPDE 4 antibody GMP-PDE beta antibody PDE 6 beta antibody PDE 6B antibody PDEB antibody Phosphodiesterase 6B antibody Rd 1 antibody Rod cGMP specific 3' 5' cyclic phosphodiesterase beta subunit antibody Rod cGMP-specific 3'' antibody RP40 antibody

General Information
Product	PDE6 Gamma Antibody
Description	Affinity Purified Retinal cone Phosphodiesterase 6 gamma Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Bovine, Human, Mouse, Rat
Immunogen	Synthetic cyclic peptide common to all PDE6 gamma variants.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.68 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DOT Blot	1:10,000
ELISA	1:10,000
Immunohistochemistry	1:50-1:200
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Overview	Visual perception
Molecular Function	3',5'-cyclic-nucleotide phosphodiesterase activity, cGMP binding
Alternative Nomenclature	5''-cyclic phosphodiesterase subunit gamma antibody GMP-PDE gamma antibody PDE 6 antibody PDEG antibody Phosphodiesterase 6G cGMP Specific antibody Retinal Rod Photoreceptor cGMP Phosphodiesterase gamma antibody RP57 antibody

General Information
Product	PDE7A Antibody
Description	Affinity Purified cAMP-specific cyclic nucleotide phosphodiesterase PDE7A3 Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic cyclic peptide common to all PDE7A variants
Specificity	This antibody is specific for PDE7A variants and will not cross-react with PDE7B or other PDE family members.
Accession #	GenBank: AAK57640.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.50-0.75 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunohistocheistry	1:100
Immunoprecipitation	1:250
Western Blot	1:500
Protein
Uniprot #	Q13946
Overview	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.
Molecular Function	3', 5' -cyclic-AMP phosphodiesterase activity
Subcellular Location	Isoform PDE7A1 : Cytoplasm › cytosol, Isoform PDE7A2: Cytoplasm
Expression	PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart.
Structure	Interacts with CBFA2T3
Alternative Nomenclature	HCP 1 antibody P2A antibody PDE 7 antibody PDE1/PDE2 yeast human complement of antibody PDE7A antibody Phosphodiesterase 7A antibody Phosphodiesterase isozyme 7 antibody Rolipram insensitive phosphodiesterase type 7 antibody TM 22 antibody

General Information
Product	Phospho-PDE7A Antibody
Description	Affinity Purified High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A Antibody
Verified Applications	ELISA, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Phosphorylated Synthetic cyclic peptide common to all PDE7A variants
Specificity	This antibody is specific for PDE7A variants and will not cross-react with PDE7B or other PDE family members.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.50-0.75 µg/µl in antibody stabilization buffer
Immunoglobulin	IgG
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
ELISA	1:10,000
Immunoprecipitation	1:250
Western Blot	1:500
Protein
Uniprot #	P70453
Overview	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.
Molecular Function	Hydrolase, 3', 5' -cyclic-AMP phosphodiesterase activity
Subcellular Location	Cytoplasm
Expression	PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart. Developmentally regulated. PDE7A1 and PDE7A2 are found in several fetal tissues, expression is reduced throughout development. It persists strongly only in adult skeletal muscle.
Structure	Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
Alternative Nomenclature	HCP 1 antibody P2A antibody PDE 7 antibody PDE 7A antibody PDE1/PDE2 yeast human complement of antibody PDE7 antibody PDE71 antibody Phosphodiesterase 7A antibody Phosphodiesterase isozyme 7 antibody Rolipram insensitive phosphodiesterase type 7 antibody TM22 antibody

General Information
Product	PDE8B Antibody
Description	Affinity Purified Phosphodiesterase 8B Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Bovine, Human, Monkey, Mouse, Rat
Immunogen	Synthetic cyclic peptide common to all PDE8B variants.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.5 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:200
Immunofluorescence	1:200
Immunohistochemistry	1:200
Immunoprecipitation	1:250
Western Blot	1:500-1:2,000
Protein
Uniprot #	E9PXX4
Overview	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.
Molecular Function	3',5'-cyclic-AMP phosphodiesterase activity, Hydrolase, Metal-binding
Expression	Widely expressed
Structure	Belongs to the cyclic nucleotide phosphodiesterase family. PDE8B subfamily. Contains 1 PER-ARNT-SIM (PAS) domain.
Alternative Nomenclature	3' 5' cyclic nucleotide phosphodiesterase 8B antibody Cell proliferation-inducing gene 22 protein antibody FLJ11212 antibody High affinity cAMP specific and IBMX insensitive 3' 5' cyclic phosphodiesterase 8B antibody HSPDE 8B antibody PDE8B antibody Phosphodiesterase8B antibody PIG22 antibody

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PDE4B Antibody

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