General Information

Product

Phospho-PDE11A (S117) Antibody

Description

Affinity Purified Phosphorylated Cyclic Nucleotide Phosphodiesterase 11A Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 75-125 on PDE11A protein.  Phosphorylated Ser 117.

Accession #

NCBI:  NP_543169

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.69 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

Q9HCR9

Overview

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.

Molecular Function

Hydrolase, metal-ion binding, cGMP binding

Subcellular Location

Cytoplasm

Expression

Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex.

Alternative Nomenclature

5''-cyclic-AMP and -GMP phosphodiesterase 11A antibody

cAMP and cGMP cyclic nucleotide phosphodiesterase 11A antibody

cGMP phosphodiesterase 11A antibody

Cyclic nucleotide phosphodiesterase 11A1 antibody

Dual 3' 5' cyclic AMP and GMP phosphodiesterase 11A antibody

Dual 3'' antibody phosphodiesterase 11A antibody

FLJ23693 antibody

MGC133355 antibody

MGC133356 antibody

PDE 11A antibody

pde11 antibody

PDE11A antibody

PDE11A1 antibody

pde11a2 antibody

Phosphodiesterase 11A antibody

PPNAD2 antibody

General Information

Product

PDE1A Antibody

Description

Affinity Purified Phosphodiesterase 1A Antibody C-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 51-101 on human PDE1A protein. 

Accession #

NCBI:  NP001009978.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500-1:1,000

Protein

Uniprot #

Q9JLL9

Overview

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.

Molecular Function

Hydrolase, calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity, metal ion binding

Subcellular Location

Cytosol

Expression

Several tissues, including brain, kidney, testes and heart.

Structure

Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.

Alternative Nomenclature

3' 5' cyclic nucleotide phosphodiesterase antibody
61 kDa Cam PDE antibody

Calcium/calmodulin dependent 3' 5' cyclic nucleotide phosphodiesterase 1A antibody Calcium/calmodulin-dependent 3'' antibody
Calmodulin-dependent Phosphodiesterase antibody
Cam PDE 1A antibody

HSPDE1A antibody
MGC26303 antibody
PDE1A antibody

Phosphodiesterase 1A antibody
Phosphodiesterase 1A calmodulin dependent antibody

General Information

Product

Pan PDE5A Antibody

Description

cGMP-specific 3',5'-cyclic phosphodiesterase isoform 1 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Chicken, Human

Immunogen

Recombinant protein common to all PDE5A variants corresponding to human PDE5A protein.

Accession #

NCBI:  NP_001074

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500-1:1,000

Protein

Uniprot #

O76074

Overview

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.

Molecular Function

Hydrolase, 3',5'-cyclic-GMP phosphodiesterase activity, cGMP binding

Subcellular Location

cytosol

Expression

Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.

Alternative Nomenclature

5''-cyclic phosphodiesterase antibody

CGB PDE antibody

cGMP binding cGMP specific 3' 5' cyclic nucleotide phosphodiesterase antibody

cGMP binding/cGMP specific phosphodiesterase antibody

cGMP specific phosphodiesterase PDE5A antibody

cGMP specific phosphodiesterase type 5A antibody

cGMP-specific 3'' antibody

CN5A antibody

CN5N antibody

PDE 5 antibody

PDE 5A antibody

PDE5A antibody

Phosphodiesterase 5A antibody

Phosphodiesterase 5A cGMP specific antibody

Phosphodiesterase isozyme 5 antibody

General Information

Product

PDE12 Antibody

Description

Affinity Purified Phosphodiesterase 12 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 370-420 on rat PDE12 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q6TUH0

Overview

Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

Molecular Function

Metal ion binding; poly (A)-specific ribonuclease activity

Subcellular Location

Mitochondrion Matrix

Expression

Ubiquitous

Structure

Belongs to the CCR4/nocturin family.

Alternative Nomenclature

2 PDE antibody

2' 5' phosphodiesterase 12 antibody

2' phosphodiesterase antibody

2'-PDE antibody

DKFZp667B1218 antibody

Pde12 antibody

Phosphodiesterase 12 antibody

General Information

Product

PDE12 Antibody

Description

Affinity Purified Phosphodiesterase 12 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Rat

Immunogen

Synthetic peptide taken within amino acid region 570-620 on human PDE12 protein.

Accession #

NCBI:  NP_001014020

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q6L8Q7

Overview

Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

Molecular Function

Metal ion binding; poly (A)-specific ribonuclease activity

Subcellular Location

Mitochondrion Matrix

Expression

Ubiquitous

Structure

Belongs to the CCR4/nocturin family.

Alternative Nomenclature

2 PDE antibody

2' 5' phosphodiesterase 12 antibody

2' phosphodiesterase antibody

2',5'-phosphodiesterase 12 antibody

2'-PDE antibody

2-PDE antibody

2PDE antibody

DKFZp667B1218 antibody

Pde12 antibody

PDE12_HUMAN antibody

Phosphodiesterase 12 antibody

General Information

Product

Phospho-PDE11A (S162) Antibody

Description

Affinity Purified Phosphorylated Cyclic Nucleotide Phosphodiesterase 11A Antibody C-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Rat

Immunogen

Synthetic peptide taken within amino acid region 100-200 on PDE11A protein. Phosphorylated Serine 162 residue.

Accession #

NCBI:  NP_543169

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.69 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

Q9HCR9

Overview

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.

Molecular Function

Hydrolase, metal-ion binding, cGMP binding

Subcellular Location

Cytoplasm

Expression

Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex.

Alternative Nomenclature

5''-cyclic-AMP and -GMP phosphodiesterase 11A antibody

cAMP and cGMP cyclic nucleotide phosphodiesterase 11A antibody

cGMP phosphodiesterase 11A antibody

Cyclic nucleotide phosphodiesterase 11A1 antibody

Dual 3' 5' cyclic AMP and GMP phosphodiesterase 11A antibody

Dual 3'' antibody phosphodiesterase 11A antibody

FLJ23693 antibody

MGC133355 antibody

MGC133356 antibody

PDE 11A antibody

pde11 antibody

PDE11A antibody

PDE11A1 antibody

pde11a2 antibody

Phosphodiesterase 11A antibody

PPNAD2 antibody

General Information

Product

PDE2A1 Antibody

Description

Affinity Purified Phosphodiesterase 2A1 Antibody N-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide corresponding to region within amino acids 1-50 on N-terminus of human PDE2A1 protein.

Accession #

NCBI:  NP_001230713.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

O00408

Overview

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.

Isoform PDE2A2: Regulates Mitochondrial cAMP Levels and Respiration.

Molecular Function

Calcium channel activity, cAMP binding, cGMP binding, cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; drug binding; metal ion binding; protein homodimerization activity; TPR domain binding.

Subcellular Location

Cytoplasm

Expression

Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.

Structure

Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.

Contains 2 GAF domains.

Alternative Nomenclature

Phosphodiesterase 2A 1

General Information

Product

PDE2A2 Antibody

Description

Affinity Purified Phosphodiesterase 2A2 Antibody N-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to region within amino acids 1-50 on N-terminus of human PDE2A2 protein.

Accession #

NCBI:  NP_001230713.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

O00408

Overview

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.

Isoform PDE2A2: Regulates Mitochondrial cAMP Levels and Respiration.

Molecular Function

Calcium channel activity, cAMP binding, cGMP binding, cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; drug binding; metal ion binding; protein homodimerization activity; TPR domain binding

Subcellular Location

Mitochondrion matrix

Expression

Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.

Structure

Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.

Contains 2 GAF domains.

Alternative Nomenclature

Phosphodiesterase 2A 2

General Information

Product

PDE2A3 Antibody

Description

Affinity Purified Phosphodiesterase 2A3 Antibody N-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to region within amino acids 1-50 on N-terminus of human PDE2A3 protein.

Accession #

NCBI:  NP_002590.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

O00408

Overview

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.

Molecular Function

Calcium channel activity, cAMP binding, cGMP binding, cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; drug binding; metal ion binding; protein homodimerization activity; TPR domain binding

Subcellular Location

Cell membrane; Lipid-anchor

Expression

Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.

Structure

Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.

Contains 2 GAF domains.

Alternative Nomenclature

Phosphodiesterase 2A 3

General Information

Product

Phospho-PDE11A (S163) Antibody

Description

Affinity Purified Phosphorylated PDE11A (Serine 163) Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 100-200 on rat PDE11A protein. Phosphorylated Ser 163.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Modification

Phosphorylated

Storage

-20C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:500-1:5,000

Protein

Uniprot #

Q8VID6

Overview

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (By similarity).

Molecular Function

3',5'-cyclic-AMP phosphodiesterase activity

3',5'-cyclic-GMP phosphodiesterase activity

3',5'-cyclic-nucleotide phosphodiesterase activity

cGMP binding Source: RGD

cGMP-stimulated cyclic-nucleotide phosphodiesterase activity

cyclic-nucleotide phosphod

Expression

Isoform 1 is expressed in brain, heart, kidney and liver, but not in prostate. Isoform 2 is specifically expressed in testis. Isoform 3 is expressed in various tissues including brain, lung, skeletal muscle, spleen, testis and prostate.

Structure

Belongs to the cyclic nucleotide phosphodiesterase family.

Alternative Nomenclature

5''-cyclic-AMP and -GMP phosphodiesterase 11A antibody

cAMP and cGMP cyclic nucleotide phosphodiesterase 11A antibody

cAMP and cGMP phosphodiesterase 11A antibody

cAMP phosphodiesterase 11A antibody

cGMP phosphodiesterase 11A antibody

Cyclic nucleotide phosphodiesterase 11A antibody

Dual 3'' antibody

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A antibody

FLJ23693 antibody

MGC133355 antibody

MGC133356 antibody

PDE 11A antibody

pde11 antibody

PDE11_HUMAN antibody

PDE11A antibody

PDE11A1 antibody

pde11a2 antibody

Phosphodiesterase 11A antibody

PPNAD2 antibody