General Information |
|
Product |
ROCK1 Antibody BIOTIN-Conjugated |
Description |
BIOTIN-Conjugated Rho-associated protein kinase 1 Antibody |
Verified Applications |
ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Monkey, Mouse, Pig, Rat |
Immunogen |
Synthetic peptide taken within amino acid region spanning 850-900 on human ROCK1 protein. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.57 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunohistochemistry | 1:50-1:100 |
Immunoprecipitation | 1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. |
Molecular Function |
Kinase, Serine/threonine-protein kinase, Transferase |
Subcellular Location |
Cytoplasm, Golgi apparatus membrane; Peripheral membrane protein, Cell projection |
Expression |
Detected in blood platelets. |
Structure |
Homodimer. Interacts with RHOB, RHOC, MYLC2B and PTEN. Interacts with ITGB1BP1 (via N-terminus and PTB domain) (By similarity). Interacts with RHOA (activated by GTP), CHORDC1, DAPK3, GEM, JIP3, RHOE, PPP1R12A, PFN1, LIMK1, LIMK2 and TSG101. Interacts with FHOD1 in a Src-dependent manner. |
Alternative Nomenclature |
coiled-coil-containing protein kinase 1 antibody NY REN 35 antigen antibody p160 Rhoassociated coiled coil-forming protein kinase antibody p160 ROCK1 antibody PRO0435 antibody Renal carcinoma antigen NY REN 35 antibody Rho associated coiled coil containing protein kinase 1 antibody Rho-alpha kinase antibody Rho-associated protein kinase 1 antibody Rok antibody rokalpha antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-ROCK1 | |||
|
ROCK1-101AP | |||
|
ROCK1-FITC | |||
|
PC-ROCK1 | |||
Display accessory details |
Select your currency:
(c) FabGennix International Inc.