General Information
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Product
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IRF8 Peptide
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide taken within amino acid region 350-400 on mouse Interferon Regulatory Factor 8 protein.
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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P23611
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Overview
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Plays a role as a transcriptional activator or repressor. Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (PubMed:22992524).
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Molecular Function
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DNA binding
DNA binding transcription factor activity
RNA polymerase II proximal promoter sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
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Subcellular Location
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Nucleus, cytoplasm
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Expression
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Predominantly in lymphoid tissues.
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Structure
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Belongs to the IRF family.
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Alternative Nomenclature
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H ICSBP antibody
HICSBP antibody
ICSBP 1 antibody
Interferon consensus sequence binding protein 1 antibody
Interferon regulatory factor 8 antibody
IRF 8 antibody
MYLS antibody
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