General Information
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Product
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alpha Synuclein Antibody
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Description
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Affinity Purified alpha-synuclein isoform NACP112 Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Monkey, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 62-112 unique sequence on alpha-synuclein isoform NACP 112 protein.
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Specificity |
This antibody will not detect NACP140. |
Accession #
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NCBI: NP_009292
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.50 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Purification Method |
Immobilized antigen affinity chromatography. |
Immunoglobulin |
IgG |
Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:20,000
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ELISA
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1:20,000
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Immunohistochemistry |
1:100 |
Immunoprecipitation |
1:200 |
Western Blot
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1:500
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Protein
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Uniprot #
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P37840
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Overview
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May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
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Molecular Function
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Alpha-tubulin binding, Calcium-ion binding, copper ion binding
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Subcellular Location
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cytoplasm, Membrane, Nucleus, Cell junction > synapse
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Expression
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Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.
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Structure
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Soluble monomer which can form filamentous aggregates. Interacts with UCHL1. Interacts with phospholipase D and histones
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Alternative Nomenclature
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Alpha synuclein
MGC105443
MGC110988
MGC127560
NACP
PARK 1
PARK 4
PD 1
SNCA
SYN
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