Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses. Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.
Molecular Function
cadherin binding
RNA polymerase II proximal promoter sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
signal transducer activity
transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Subcellular Location
Nucleus, centrosome, cytoplasm
Structure
Belongs to the CC2D1 family.
Alternative Nomenclature
Akt kinase interacting protein 1 antibody
Coiled coil and C2 domain containing protein 1A antibody
Five repressor element under dual repression binding protein 1 antibody
FRE under dual repression binding protein 1 antibody