General Information

Product

BACE2 A/C Antibody

Description

Affinity Purified Beta Secretase beta-site APP cleaving Enzyme 2A/C Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Predicted: Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 490-518 on human BACE2 protein.

Accession #

GenBank: AAQ89286

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.72-0.76 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9Y5Z0

Overview

Responsible for the proteolytic processing of the amyloid precursor protein. Cleaves APP between 690 and 691 leading to the generation and extracellular release of beta-cleaved soluble APP and C-terminal fragment which is later released by gamma-secretase.

Molecular Function

Aspartic-type endopeptidase activity.

Subcellular Location

Endoplasmic reticulum, Endosome, Golgi apparatus; Membrane

Expression

Neurons within the hippocampus, frontal cortex and temporal cortex. Lower expression in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Also found in spinal cord, medulla oblongata, substania nigra and locus coruleus. Expressed in ductal epithelium of prostate.

Structure

Belongs to the peptidase A1 family.

Alternative Nomenclature

ALP 56 antibody

ASP1 antibody

ASP21 antibody

Aspartic Like Protease 56kDa antibody

Downs Syndrome Region Aspartic Protease antibody

DRAP antibody

Memapsin-1 antibody

Membrane associated aspartic protease 1 antibody

Theta-secretase antibody

General Information

Product

Fbx32 Antibody

Description

Affinity Purified Atrogin Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Rat, Mouse

Immunogen

Synthetic peptide taken within amino acid region 240-280 on Atr1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q969P5

Overview

Substrate recognition component of a SCF E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Molecular Function

Ubl conjugation pathway

Subcellular Location

Cytoplasm; Nucleus

Expression

Cardiac and skeletal muscle

Structure

Contains 1 F-box domain

Alternative Nomenclature

Atrophy gene 1 antibody

F-box only protein 32 antibody

fbxo25 antibody

Muscle atrophy F-box protein antibody

General Information

Product

BACE2 B Antibody

Description

Affinity Purified beta-secretase 2 isoform B preproprotein Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 350-396 on human BACE2B protein.

Accession #

NCBI:  NP_620477

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.59 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9Y5Z0

Overview

Responsible for the proteolytic processing of the amyloid precursor protein. Cleaves APP between 690 and 691 leading to the generation and extracellular release of beta-cleaved soluble APP and C-terminal fragment which is later released by gamma-secretase.

Molecular Function

Aspartic-type endopeptidase activity.

Subcellular Location

Endoplasmic reticulum, Endosome, Golgi apparatus; Membrane

Expression

Neurons within the hippocampus, frontal cortex and temporal cortex. Lower expression in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Also found in spinal cord, medulla oblongata, substania nigra and locus coruleus. Expressed in ductal epithelium of prostate.

Structure

Belongs to the peptidase A1 family.

Alternative Nomenclature

ALP 56 antibody

ASP1 antibody

ASP21 antibody

Aspartic Like Protease 56kDa antibody

Downs Syndrome Region Aspartic Protease antibody

DRAP antibody

Memapsin-1 antibody

Membrane associated aspartic protease 1 antibody

Theta-secretase antibody

General Information

Product

MURF1 Antibody

Description

Affinity Purified E3 ubiquitin-protein ligase TRIM 63 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken wtihin amino acid region 270-310 on human MURF1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.54-0.57 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q969Q1

Overview

E3 ubiquitin ligase,Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids.

Molecular Function

ligase activity;ubiquitin-protein transferase activity

Subcellular Location

Cytoplasm, Nucleus

Expression

Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris

Structure

Homodimer. Homooligomer and heterooligomer

Alternative Nomenclature

E3 ubiquitin-protein ligase TRIM63 antibody

IRF antibody

MURF 1 antibody

MURF2 antibody

RNF 28 antibody

SMRZ antibody

TRIM63 antibody

Ubiquitin ligase TRIM63 antibody

General Information

Product

RCE1 Antibody Affinity Purified

Description

Affinity Purified RCE1 homolog, prenyl protein peptidase Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid sequence 300-350 on human RCE1 protein.

Accession #

GenBank: AAH93726.1  

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9Y256

Overview

Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins.  Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B, and G-gamma-1.

Molecular Function

Hydrolase

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane

Structure

Ubiquitous

Alternative Nomenclature

CAAX prenyl protease 2 antibody

FACE2 antibody

Farnesylated proteins converting enzyme 2 antibody

Prenyl protein specific endoprotease 2 antibody

RCE1 homolog prenyl protein peptidase antibody

RCE1A antibody

RCE1B antibody

General Information

Product

TMPRSS2 Antibody Affinity Purified

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 470-530 on human TMPRSS2 protein.

Accession #

GenBank: BAB70683.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.59-0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q920K3

Molecular Function

scavenger receptor activity, serine-type endopeptidase activity

Alternative Nomenclature

D16Ertd61e antibody

Epitheliasin antibody

PP9284 antibody

PRSS10 antibody

Serine protease 10 antibody

TMPRSS2 ERG FUSION GENE, INCLUDED antibody

TMPRSS2 ETV1 FUSION GENE, INCLUDED antibody

Transmembrane protease serine 2 catalytic chain antibody

Transmembrane protease, serine 2, EC 3.4.219 antibody

General Information

Product

UFD1L Antibody Affinity Purified

Description

Affinity Purified UFD1L Purified 20 kDa UFD1L protein Antibody

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Purified 20 kDa UFD1L protein

Accession #

GenBank: CAG30493.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q92890

Overview

Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins  from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.

Molecular Function

Ubiquitin-specific protease activity

Subcellular Location

Nucleus; Cytosol

Expression

Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney.

Structure

Heterodimer with NPLOC4, this heterodimer binds VCP and inhibits Golgi membrane fusion. Interacts with USP13.

Alternative Nomenclature

UB fusion protein 1 antibody

Ubiquitin fusion degradation 1 like (yeast) antibody

Ubiquitin fusion degradation protein 1 homolog antibody

UFD1 antibody

UFD1L antibody

General Information

Product

Phospho PRP19 Antibody

Description

Affinity Purified Phosphorylated pre-mRNA-processing factor 19 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Phosphorylated synthetic peptide taken within amino acid region 200-300 on rat PRP19F protein.

Accession #

NCBI:  NP_647549

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:2,000

ELISA

1:2,000

Western Blot

1:500-1:1,000

Protein

Uniprot #

Q9JMJ4

Overview

Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3.

Molecular Function

Ligase, DNA binding, ubiquitin-ubiquitin ligase activity

Structure

Homotetramer. Component of the Prp19 complex/PRP19C/Nineteen complex/NTC and related complexes described as PRP19-CDC5L splicing complex and PSO4 complex. A homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2 constitute the core of those complexes. The interaction with CDC5L, PLRG1 and BCAS2 is direct within this core complex.

Alternative Nomenclature

hPso4 antibody

NMP200 antibody

Nuclear matrix protein 200 antibody

pre mRNA processing factor 19 antibody

PRP19 antibody

PRP19/PSO4 homolog antibody

PRPF19 antibody

PSO4 antibody

psoralen 4 antibody

Senescence evasion factor antibody

SNEV antibody

UBOX4 antibody

General Information

Product

PRP19 Antibody Affinity Purified

Description

Affinity Purified pre-mRNA-processing factor 19 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 200-300 on rat PRP19F protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:2,000

ELISA

1:2,000

Western Blot

1:500-1:1,000

Protein

Uniprot #

Q9JMJ4

Overview

Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3.

Molecular Function

Ligase, DNA binding, ubiquitin-ubiquitin ligase activity

Structure

Homotetramer. Component of the Prp19 complex/PRP19C/Nineteen complex/NTC and related complexes described as PRP19-CDC5L splicing complex and PSO4 complex. A homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2 constitute the core of those complexes. The interac

Alternative Nomenclature

hPso4 antibody

NMP200 antibody

Nuclear matrix protein 200 antibody

pre mRNA processing factor 19 antibody

PRP19 antibody

PRP19/PSO4 homolog antibody

PRPF19 antibody

PSO4 antibody

psoralen 4 antibody

Senescence evasion factor antibody

SNEV antibody

UBOX4 antibody

General Information

Product

Calpain Antibody

Description

Affinity Purified Calpain Schistosoma Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Reactivity

S. mansoni

Immunogen

Synthetic peptide taken within amino acid region 700-758 on Schistosoma mansoni Calpain protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Dot blot

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P27730

Overview

Calcium-activated non-lysosomal thiol-proteases.

Molecular Function

Calcium, Metal-binding.

Subcellular Location

Intracellular

Expression

Sporocysts and adult worms

Structure

Belongs to the peptidase C2 family; 1 Calpain catalytic domain; 2 EF-hand domains

Alternative Nomenclature

Calcium activated neutral proteinase 1 antibody

Calpain 1 (mu/I) large subunit antibody

CANP 1 antibody

Cell proliferation inducing protein 30 antibody

Micromolar Calpain antibody

Mu Calpain antibody

muCANP antibody

muCL antibody