General Information |
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Product |
ROCK2 Positive Control |
Description |
Western Blot Positive Control Rho-associated protein kinase 2 |
Verified Applications |
WB |
Form |
Purified Protein |
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Quantity |
5 Applications |
Volume |
Inquire |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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Western Blot |
1:500 |
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Uniprot # |
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Overview |
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. |
Molecular Function |
Kinase, Serine/threonine-protein kinase, Transferase |
Subcellular Location |
Cytoplasm, Cell membrane; Peripheral membrane protein, Nucleus |
Structure |
Homodimer. Interacts with IRS1, RHOB and RHOC. Interacts with RHOA (activated by GTP), PPP1R12A, CHORDC1, SORL1, EP300 and BRCA2. Interacts with NPM1 and this interaction enhances its activity. Interacts with RAF1. |
Alternative Nomenclature |
coiled-coil-containing protein kinase 2 antibody KIAA0619 antibody p164 ROCK 2 antibody Rho associated, coiled coil containing protein kinase II antibody ROK alpha antibody |
Protein information supplied by UniProt
FabGennix ROCK2 Antibody has been used in 1 Publication |
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Gong, Weijun, et al. "Deletion of long noncoding RNA EFNA3 aggravates hypoxia‐induced injury in PC‐12 cells by upregulation of miR‐101a." Journal of cellular biochemistry 120.1 (2019) PMID30125989
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Western Blot; Rat |
Publishing research using ROCK2-201AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
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ROCK2-201AP | |||
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ROCK2-FITC | |||
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P-ROCK2 | |||
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ROCK2-BIOTIN | |||
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(c) FabGennix International Inc.