General Information
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Product
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SIRT5 Positive Control
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Description
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Western Blot Positive Control Sirtuin 5 (silent mating type information regulation 2 homolog) 5
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Verified Applications
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WB
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Immunogen
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Purified Protein
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Accession #
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NCBI: NP_001004256.1
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Physical Properties
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Quantity
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5 Applications
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Volume
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Inquire
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Form
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Western Blot Positive Control
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Storage
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-20⁰C for long term storage
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Application Protocol
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Western Blot
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1:500
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Protein
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Uniprot #
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Q68FX9
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Overview
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NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.
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Molecular Function
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Hydrolase; Metal-binding; NAD; Zinc
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Subcellular Location
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Isoform 1: Cytoplasm, Mitochondrion Isoform 2: Mitochondrion
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Expression
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Widely expressed.
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Structure
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Interacts with CPS1 (By similarity). Monomer. Homodimer. Forms homodimers upon suramin binding.
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Alternative Nomenclature
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NAD dependent deacetylase sirtuin 5 antibody
Regulatory protein SIR2 homolog 5 antibody
Silent mating type information regulation 2 Sir2 like 5 antibody
SIR2-like protein 5 antibody
SIR2L5 antibody
Sirtuin type 5 antibody
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