General Information |
|
Product |
CXCR4 Antibody BIOTIN-Conjugated |
Verified Applications |
CM, ELISA, ICC, IF, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 15-65 on CXCR4 protein. |
Accession # |
GenBank: CAA12166 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.68-0.75 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:10,000 |
Immunocytochemistry |
1:250 |
Immunofluorescence |
1:250 |
Immunohistochemistry |
1:250 |
Immunoprecipitation |
1:250 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. |
Molecular Function |
Host-virus Interaction |
Subcellular Location |
Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome |
Expression |
Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. |
Structure |
Monomer. Can form dimers. |
Alternative Nomenclature |
C-X-C chemokine receptor type 4 antibody CD184 antibody Chemokine CXC Motif Receptor 4 antibody CXCR4 antibody D2S201E antibody FB22 antibody Fusin antibody HM89 antibody HSY3RR antibody LAP 3 antibody LCR1 antibody LESTR antibody Leukocyte derived seven transmembrane domain receptor antibody Lipopolysaccharide associated protein 3 antibody Neuropeptide Y receptor Y3 antibody NPY3R antibody NPYR antibody NPYRL antibody Probable G protein coupled receptor lcr1 homolog antibody SDF 1 receptor antibody Stromal cell derived factor 1 receptor antibody WHIM antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
CXCR4-401AP | |||
|
P-CXCR4 | |||
|
CXCR4-FITC | |||
|
PC-CXCR4 | |||
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