General Information |
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Product |
Sialoadhesin Positive Control |
Description |
Western Blot Positive Control CD169 |
Verified Applications |
WB |
Accession # |
NCBI: NP_075556 |
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Quantity |
5 Applications |
Volume |
Inquire |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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Western Blot |
1:500 |
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Uniprot # |
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Overview |
Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells.Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis. |
Molecular Function |
Carbohydrate binding; Cell adhesion; Endocytosis |
Subcellular Location |
Isoform 1: Cell membrane; Isoform 2: Secreted |
Expression |
Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophagrophages in rheumatoid arthritis. |
Structure |
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Contains 16 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
Alternative Nomenclature |
CD169 antibody dJ1009E24.1 antibody DKFZp667F058 antibody FLJ00051 antibody FLJ00055 antibody FLJ00073 antibody FLJ00411 antibody FLJ32150 antibody sialic acid binding Ig-like lectin 1, sialoadhesin antibody Sialic acid-binding Ig-like lectin 1 antibody Sialoadhesin antibody Siglec 1 antibody SN antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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CD169-101AP | |||
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P-CD169 | |||
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CD169-FITC | |||
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CD169-BIOTIN | |||
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