General Information |
|
Product |
AGE Peptide |
Description |
Antigenic Blocking Peptide Advance Glycated Endproduct Antibody |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Purified glycated ribonuclease corresponding to AGE. Glycated ribonuclease (RNase) prepared by incubating RNase with glucose at 37⁰C for several months. |
|
|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
|
|
Competition/Depletion assay |
|
|
|
Overview |
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. |
Molecular Function |
Inflammatory Response |
Subcellular Location |
Isoform 1 : Cell membrane; Single-pass type I membrane protein Isoform 2 : Secreted Isoform 10 : Cell membrane 1 Publication; Single-pass type I membrane protein |
Expression |
Endothelial cells. |
Structure |
Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked. |
Alternative Nomenclature |
Advanced glycation end products antibody AGEs antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
AGE-101AP | |||
|
AGE-FITC | |||
|
AGE-BIOTIN | |||
|
PC-AGE | |||
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