General Information |
|
Product |
MAVS Antibody FITC-Conjugated |
Description |
FITC-Conjugated Mitochondrial Anti Viral-Signaling Protein Antibody |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human |
Immunogen |
Synthetic peptide taken within amino acid region 500-540 on on human mitochondrial antiviral-signaling protein isoform 1. |
Accession # |
NCBI: NP_065797 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:10,000 |
Immunoprecipitation |
1:150 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. |
Molecular Function |
Antiviral defense, Host-virus interaction, Immunity, Innate immunity |
Subcellular Location |
Mitochondrion outer membrane, Mitochondrion, Peroxisome |
Expression |
Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes. |
Structure |
Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58/RIG-I and IFIH1/MDA5. The transmembrane domain and residues 300-444 are essential for its interaction with DHX58/LGP2. |
Alternative Nomenclature |
CARD adapter inducing interferon beta antibody IFN B promoter stimulator 1 antibody Interferon beta promoter stimulator protein 1 antibody Ips 1 antibody MAVS antibody Mitochondrial anti viral signaling protein antibody Putative NF kappa B activating protein 031N antibody Virus induced signaling adapter antibodyVISA antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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MAVSP-101AP | |||
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MAVSP-BIOTIN | |||
|
P-MAVSP | |||
|
PC-MAVSP | |||
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