General Information
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Product
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THAP1 Antibody BIOTIN
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Description
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BIOTIN-Conjugated THAP domain-containing protein 1 Antibody
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human
Predicted: Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 150-210 on human THAP domain-containing protein 1.
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Accession #
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GenBank: CAG33537
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5-1.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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BIOTIN-Conjugated
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:10,000
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Immunocytochemistry
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1:50-1:150
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Immunohistochemistry
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1:50-1:150
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Immunoprecipitation
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1:200
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Western Blot
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1:500
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Protein
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Uniprot #
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Q9NVV9
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Overview
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DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
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Molecular Function
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Identical protein binding, Sequence-specific DNA binding, Zinc ion binding
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Subcellular Location
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Nucleus > nucleoplasm, PML body
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Expression
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Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta.
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Structure
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Belongs to the THAP1 family.
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Alternative Nomenclature
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Nuclear proapoptotic factor antibody
THAP 1 antibody
THAP domain containing apoptosis associated protein 1 antibody
THAP domain containing protein 1 antibody
THAP domain protein 1 antibody
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