DNA PKcs Antibody

Product no.: DNPK1-101Y
$285.00


General Information

 

 

Product

 

DNA PKcs Antibody

Description

Affinity Purified DNA-dependent protein kinase catalytic subunit Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Chicken

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 4000-4128 of human DNPK1 protein.


Physical Properties

 

 

Quantity

 

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgY

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20C for long term storage


Application Protocol

 

ELISA

 

1:10,000

Immunohistochemistry 1:50-1:150

Immunoprecipitation

1:200

Western Blot

1:500


Protein

 

Uniprot #

 

P78527

Overview

Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage.

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Nucleus

Expression

Found in axons of the central and peripheral nervous system;differentiated cell types of the intestine

Structure

Belongs to the immunoglobulin superfamily. DCC family;Contains 6 fibronectin type-III domains;Contains 4 Ig-like C2-type (immunoglobulin-like) domains

Alternative Nomenclature

DNA dependent protein kinase catalytic subunit antibody
DNA PK catalytic subunit antibody
DNA-PKcs antibody
DNAPK antibody
DNPK1 antibody
Hyper radiosensitivity of murine scid mutation, complementing 1 antibody
HYRC antibody
HYRC1 antibody
p350 antibody
p460 antibody
PKRDC antibody
Protein Kinase DNA Activated Catalytic Polypeptide antibody
XRCC7 antibody

   

Protein information supplied by UniProt
 

 

Accessories

Product Note Status Price
DNA PKcs FITC DNA PKcs FITC
DNPK1-FITC $375.00 *
DNA PKcs Blocking Peptide DNA PKcs Blocking Peptide
P-DNPK1 $155.00 *
DNA PKcs Antibody BIOTIN DNA PKcs Antibody BIOTIN
DNPK1-BIOTIN $375.00 *
DNA PKcs Positive Control DNA PKcs Positive Control
PC-DNPK1 $200.00 *
Display accessory details

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