General Information |
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Product |
Phospho-MLKL Positive Control |
Description |
Western Blot Positive Control Phosphorylated Mixed lineage kinase domain-like protein MLKL Antibody |
Verified Applications |
WB |
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Quantity |
5 Applications |
Volume |
Inquire |
Concentration |
The concentration of the sample is empirically set so that 20 µl per lane in Western and blotted with corresponding affinity purified antibody will give a clean band with a high signal to noise ratio on the gel. |
Form |
Western Blot Positive Control |
Modification |
Phosphorylated |
Storage |
-20?C for long term storage |
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Western Blot |
1:500-1:5,000 |
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Uniprot # |
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Overview |
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). |
Molecular Function |
ATP binding identical protein binding JUN kinase kinase kinase activity protein-containing complex binding protein kinase activity protein kinase binding |
Subcellular Location |
Nucleus, Plasma membrane, cytoplasm |
Structure |
Homooligomer (PubMed:29883610). Homotrimer; forms homotrimers on necroptosis induction (PubMed:24316671). Upon TNF-induced necrosis, forms in complex with PGAM5, RIPK1 and RIPK3 (PubMed:22265414). |
Alternative Nomenclature |
9130019I15Rik antibody FLJ34389 antibody hMLKL antibody Mixed lineage kinase domain like antibody Mixed lineage kinase domain like pseudokinase antibody Mixed lineage kinase domain-like protein antibody Mlkl antibody MLKL_HUMAN antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
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PMLKL-140AP | |||
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PMLKL-BIOTIN | |||
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PMLKL-FITC | |||
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P-PMLKL | |||
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