General Information |
|
Product |
Insulin degrading enzyme Positive Control |
Verified Applications |
WB |
Immunogen |
Purified Protein |
Accession # |
GenBank: EAW50092.1 |
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|
Quantity |
5 Applications |
Volume |
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Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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|
Western Blot |
1:500 |
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Uniprot # |
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Overview |
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. |
Molecular Function |
ATPase activity; Ubiquitin Binding; Zinc ion binding; Insulin binding; Hydrolase; Metalloprotease; Protease |
Subcellular Location |
Cytoplasm; Cell membrane; Secreted |
Structure |
Homodimer. Can form higher oligomers. Interacts (via N-terminus) with varicella-zoster virus (VZV) envelope glycoprotein E (via N-terminus); the membrane-associated isoform may function as an entry receptor for this virus. |
Alternative Nomenclature |
Abeta-degrading protease antibody FLJ35968 antibody Ide antibody insulin protease antibody Insulin-degrading enzyme antibody insulinase antibody insulysin antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
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IDE-101AP | |||
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IDE-FITC | |||
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P-IDE | |||
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IDE-BIOTIN | |||
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