General Information

Product

PDE1B Antibody

Description

Affinity Purified Pan Phosphodiesterase 1B Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on PDE1B gene.

Accession #

GenBank: EDL03912.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:50-1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:50-1:200

Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Immunoprecipitation

1:200

Western Blot

1:500-1:1,000.

Predicted molecular weight: 65 kDa.

This antibody labels multiple bands in the 65-72 kDa range all believed to be various PDE1B variants.

Protein

Uniprot #

UPI000154A3CC

Overview

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.

Molecular Function

Calmodulin-binding, cAMP, cGMP, Metal-binding

Subcellular Location

Cytoplasm

Structure

Homodimer

Alternative Nomenclature

5''-cyclic nucleotide phosphodiesterase 1B antibody

63 kDa Cam PDE antibody

Calcium/calmodulin dependent 3' 5' cyclic nucleotide Phosphodiesterase 1B antibody

PDE1B1 antibody

Cam PDE 1B antibody

PDE1B antibody

PDE1B1 antibody

PDES 1B antibody

Phosphodiesterase 1B antibody

Phosphodiesterase 1B calmodulin dependent antibody

General Information

Product

PGCA Antibody

Description

Affinity Purified Atrial natriuretic peptide receptor 1 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to C terminal amino acids 1042-1057 of Human PGCA.

Seqence:

VRTYWLLGERGCSTRG

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.85 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:25-1:250

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:25-1:250

Immunofluorescence

1:25-1:250

Immunohistochemistry

1:25-1:250

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P16066

Overview

Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.

Molecular Function

ATP binding, GTP binding, hormone binding, Protein kinase activity, G-protein coupled peptide receptor activity

Subcellular Location

Membrane; Single-pass type I membrane protein

Structure

Homodimer

Alternative Nomenclature

ANP A antibody

Atrial natriuretic peptide A type receptor antibody

Atrial natriuretic peptide receptor 1 antibody

GC A antibody

GC-A antibody

Guanylate cyclase A antibody

NPR 1 antibody

NPR A antibody

General Information

Product

PGCB Antibody

Description

Affinity Purified Atrial natriuretic peptide receptor 2 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase B protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:50-1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P20594

Overview

Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.

Molecular Function

ATP binding, GTP binding, hormone binding, Protein kinase activity, G-protein coupled peptide receptor activity

Subcellular Location

Membrane; Single-pass type I membrane protein

Structure

Belongs to the adenylyl cyclase-class-4/guanylyl cyclase family.  Contains 1 guanylate cyclase domain.  Contains 1 protein kinase domain.

Alternative Nomenclature

AMDM antibody

ANPB antibody

ANPRB antibody

peptide receptor type B antibody

Atrionatriuretic peptide receptor B antibody

GC-B antibody

GUCY2B antibody

Natriuretic peptide receptor B/guanylate cyclase B antibody

NPR-B antibody

NPR2 antibody

NPRBi antibody

General Information

Product

Particulate Guanylate Cyclase C Antibody

Description

Affinity Purified Guanlylyl Cyclase C Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase C protein.

Accession #

GenBank: AAA41201.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Western Blot

1:500

Protein

Uniprot #

P23897

Overview

Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin.

Molecular Function

Lyase, Receptor

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane

Structure

Homotrimer. Interacts via its C-terminal region with PDZK2. Interacts with the lectin chaperone VIP36

Alternative Nomenclature

ANP C antibody

ANPRC antibody

Atrial natriuretic peptide C type receptor antibody

Atrionatriuretic peptide receptor C antibody

C5orf23 antibody

FLJ14054 antibody

GUCY2B antibody

MGC22189 antibody

Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) antibody

NPR 3 antibody

NPR C antibody

Guanylyl Cyclase C antibody NPR-C antibody

General Information

Product

PGCD Antibody

Description

Affinity Purified Guanlylyl Cyclase D Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase D protein.

Accession #

GenBank: AAC42057.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Western Blot

1:500

Protein

Uniprot #

P51839

Overview

May function directly in odor recognition or in modulating the sensitivity of a subpopulation of sensory neurons to specific odors.

Molecular Function

Lyase

Subcellular Location

Membrane; Single-pass type I membrane protein

Expression

Specifically expressed in a subpopulation of olfactory sensory neurons.

Structure

Belongs to the adenylyl cyclase-class-4/guanylyl cyclase family.  Contains 1 guanylate cyclase domain.  Contains 1 protein kinase domain.

Alternative Nomenclature

CORD6 antibody

guanylate cyclase 2D membrane (retina-specific) antibody

GUC1A4 antibody

GUC2D antibody

LCA1 antibody

retGC antibody

RETGC-1 antibody

ROS-GC1 antibody

General Information

Product

PGCE Antibody

Description

Affinity Purified Guanylyl cyclase E Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase E protein.

Accession #

GenBank: L36029.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Western Blot

1:500

Protein

Uniprot #

P51840

Overview

GTP = 3',5'-cyclic GMP + diphosphate.

Molecular Function

Lyase

Subcellular Location

Membrane; Single-pass type I membrane protein

Expression

Expressed in the eye and the pineal gland.

Structure

Belongs to the adenylyl cyclase-class-4/guanylyl cyclase family.  Contains 1 guanylate cyclase domain.  Contains 1 protein kinase domain.

Alternative Nomenclature

Particulate Guanylate Cyclase E antibody

General Information

Product

PGCF Antibody Affinity Purified

Description

Affinity Purified Guanylyl Cyclase F Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase F protein.

Accession #

GenBank: L36029.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Western Blot

1:500

Protein

Uniprot #

P51842

Overview

Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.

Molecular Function

Lyase

Subcellular Location

Membrane; Single-pass type I membrane protein

Expression

Expressed only in the eye.

Structure

Belongs to the adenylyl cyclase-class-4/guanylyl cyclase family.  Contains 1 guanylate cyclase domain.  Contains 1 protein kinase domain.

Alternative Nomenclature

Particulate Guanylate Cyclase F antibody

General Information

Product

PGCG Antibody

Description

Affinity Purified Guanylyl Cyclase G Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase G protein.

Accession #

GenBank: AF024622.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Western Blot

1:500

Protein

Uniprot #

P55205

Overview

Binds to a yet not identified ligand.

Possible role in processes such as water and electrolyte balance, and muscle contraction.

Molecular Function

Lyase, Receptor

Subcellular Location

Isoform 1:  Cell membrane; Single-pass type I membrane protein.  Isoform 2:  Cytoplasm

Expression

Expressed in lung, kidney and skeletal muscle. Low levels in intestine.

Structure

Homodimer or heterodimer with NPR1.

Alternative Nomenclature

CYGF antibody

GC F antibody

guanylate cyclase 2D-like, membrane (retina-specific) antibody

Guanylate cyclase 2F antibody

GUC2DL antibody

GUC2F antibody

Gucy2f antibody

RETGC-2 antibody

retinal antibody

Rod outer segment membrane guanylate cyclase 2 antibody

ROS-GC2 antibody

General Information

Product

Phospho PGCA Antibody

Description

Affinity Purified Atrial Natriuretic peptide receptor 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 500-550 on human Atrial natriuretic peptide receptor 1 protein.

Accession #

NCBI:  XP_011507887.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P16066

Overview

Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.

Molecular Function

ATP binding, GTP binding, hormone binding, Protein kinase activity, G-protein coupled peptide receptor activity

Subcellular Location

Membrane; Single-pass type I membrane protein

Structure

Homodimer

Alternative Nomenclature

ANP A antibody

ANPR-A antibody

Atrial natriuretic peptide A type receptor antibody

Atrial natriuretic peptide receptor 1 antibody

Atrionatriuretic peptide receptor A antibody

GC A antibody

Guanylate cyclase A antibody

Guanylate cyclase antibody

GUC2A antibody

Natriuretic peptide A type receptor antibody

Natriuretic peptide receptor A/guanylate cyclase A antibody

NPR 1 antibody

NPR A antibody

General Information

Product

PREX1 Antibody

Description

Affinity Purified Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide corresponding to aino acid region 815-836 of Human PREX1. Peptide was covalently modified.

Sequence:

QEEDQADSAFPLLSLGPRLSLC

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000-1:50,000

ELISA

1:20,000-1:50,000

Western Blot

1:500-1:750

Protein

Uniprot #

Q8TCU6

Overview

Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

Molecular Function

enzyme binding, Rho GTPase activator activity, Rho guanyl-nucleotide exchange factor activity, phospholipid binding

Subcellular Location

Cytoplasm, cell membrane

Expression

Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.

Alternative Nomenclature

4 antibody

5)-dependent Rac exchanger 1 antibody

P REX1 antibody

PtdIns(3,4,5) dependent Rac exchanger 1 antibody

SET domain containing 6 antibody

Setd6 antibody